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多形性腺瘤癌变原位区域的良性肌上皮细胞如何促进肿瘤进展？

How do benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma favor tumor progression?

作者信息

Martinez Elizabeth Ferreira, de Araújo Ney Soares, de Araújo Vera Cavalcanti

机构信息

Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira 13, Ponte Preta, 13045-755, Campinas, Brazil.

出版信息

J Cell Commun Signal. 2015 Sep;9(3):279-80. doi: 10.1007/s12079-015-0298-2. Epub 2015 Jun 12.

DOI:10.1007/s12079-015-0298-2
PMID:26067907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4580688/
Abstract

In this brief commentary, we have shown how the benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma from salivary gland can favor tumor progression, not only dying by autophagy/senescence phenomena, disrupting the physical barrier, but also providing fuel for tumor progression.

摘要

在这篇简短的评论中，我们已经表明，涎腺多形性腺瘤原位癌区域的良性肌上皮细胞如何促进肿瘤进展，不仅通过自噬/衰老现象死亡，破坏物理屏障，还为肿瘤进展提供“燃料”。

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本文引用的文献

1
Effect of cellular senescence on the growth of HER2-positive breast cancers.细胞衰老对 HER2 阳性乳腺癌生长的影响。
J Natl Cancer Inst. 2015 May 13;107(5). doi: 10.1093/jnci/djv020. Print 2015 May.
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Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model.肌上皮细胞的细胞衰老和自噬参与多形性腺瘤癌变原位区域向浸润性癌的进展。一种体外模型。
J Cell Commun Signal. 2015 Sep;9(3):255-65. doi: 10.1007/s12079-015-0291-9. Epub 2015 Apr 21.
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In vitro influence of the extracellular matrix in myoepithelial cells stimulated by malignant conditioned medium.体外恶性条件培养基对肌上皮细胞的细胞外基质的影响。
Oral Oncol. 2012 Feb;48(2):102-9. doi: 10.1016/j.oraloncology.2011.09.008. Epub 2011 Oct 12.
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FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures.成纤维细胞生长因子 2 在癌在多形性腺瘤原位结构中的肌上皮细胞中过表达。
Oncol Rep. 2010 Jul;24(1):155-60. doi: 10.3892/or_00000840.
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Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma.多形性腺瘤癌变导管内区域反应性涎腺肌上皮细胞的免疫表型
Oral Oncol. 2006 Nov;42(10):1011-6. doi: 10.1016/j.oraloncology.2005.12.021. Epub 2006 Jun 6.
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Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression.多形性腺瘤恶变（CXPA）：癌变进展相关细胞的免疫表型
Histopathology. 2005 Jun;46(6):635-41. doi: 10.1111/j.1365-2559.2005.02157.x.
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Oncogene. 2001 Jan 11;20(2):198-208. doi: 10.1038/sj.onc.1204076.