对上颌窦使用无机牛骨基质和富含生长因子的血浆进行增容术后10年所取活检组织的组织形态计量学分析：一例报告
Histomorphometric Analysis of a Biopsy Harvested 10 Years After Maxillary Sinus Augmentation With Anorganic Bovine Bone Matrix and Plasma Rich in Growth Factors: A Case Report.
作者信息
Pardiñas López Simón, Froum Stuart, Khouly Ismael
机构信息
*Former Resident, Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY; Periodontist and Oral Surgeon, Private Practice, Clínica Pardiñas, A Coruña, Spain. †Director of Clinical Research and Clinical Professor, Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY. ‡Assistant Clinical Professor, Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY; Associate Director of Periodontology & Implant Dentistry, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY.
出版信息
Implant Dent. 2015 Aug;24(4):480-6. doi: 10.1097/ID.0000000000000289.
PURPOSE
To evaluate the histologic and histomorphometric data 10 years after grafting of maxillary sinus in a case using anorganic bovine bone matrix (ABBM) and plasma rich in growth factors (PRGF).
MATERIALS AND METHODS
Histomorphometric measures were performed for newly formed bone, ABBM particles remnants, marrow spaces, and the presence of osteoblastic and osteoclastic activity.
RESULTS
Histologic analysis showed ABBM particles surrounded by new compact and mature vital bone. Osteocytes were noted within lacunae. Some osteoblastic and osteoclastic activity could be identified. The histomorphometric results were 21.7% of newly formed bone, 33.9% of ABBM, and 44% was composed of marrow spaces.
CONCLUSIONS
After 10 years postoperatively, the histologic evaluation of this case report demonstrated slow replacement of the ABBM particles by newly formed bone, even with the addition of PRGF. The residual ABBM particles were found in close contact to the newly formed bone.
目的
在一例使用无机牛骨基质（ABBM）和富含生长因子的血浆（PRGF）进行上颌窦移植的病例中，评估移植10年后的组织学和组织形态计量学数据。
材料与方法
对新形成的骨、ABBM颗粒残余物、骨髓腔以及成骨细胞和成骨细胞活性的存在进行组织形态计量学测量。
结果
组织学分析显示，ABBM颗粒被新形成的致密且成熟的活性骨包围。在骨陷窝内可见骨细胞。可识别出一些成骨细胞和成骨细胞活性。组织形态计量学结果为，新形成的骨占21.7%，ABBM占33.9%，骨髓腔占44%。
结论
术后10年，该病例报告的组织学评估表明，即使添加了PRGF，新形成的骨对ABBM颗粒的替代也很缓慢。发现残留的ABBM颗粒与新形成的骨紧密接触。
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