Department of Oral and Maxillofacial Surgery, German Armed Forces Central Hospital, Rübenacherstraße 170, 56072, Koblenz, Germany.
Department of Oral and Maxillofacial Surgery - Plastic Operations, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany.
Int J Implant Dent. 2024 May 27;10(1):26. doi: 10.1186/s40729-024-00544-z.
Particulate bovine bone substitutes (BS) are commonly used in oral regeneration. However, more literature is needed focusing on comparative analyses among various particulate bovine BS. This study evaluates pre-clinical and clinical data of different particulate bovine BS in oral regeneration.
A narrative review was conducted by screening the PubMed database Included in the review were pre-clinical and clinical studies until 2024 comparing a minimum of two distinct particulate bovine BS. In addition to examining general data concerning manufacturing and treatment processes, biological safety, physical and chemical characteristics, and graft resorption, particular emphasis was placed on assessing pre-clinical and clinical data related to ridge preservation, sinus floor elevation, peri-implant defects, and various forms of alveolar ridge augmentation utilizing particulate bovine BS.
Various treatment temperatures ranging from 300 to 1,250 °C and the employment of chemical cleaning steps were identified for the manufacturing process of particulate bovine BS deemed to possess biosecurity. A notable heterogeneity was observed in the physical and chemical characteristics of particulate bovine BS, with minimal or negligible graft resorption. Variations were evident in particle and pore sizes and the porosity of particulate bovine BS. Pre-clinical assessments noted a marginal inclination towards favorable outcomes for particulate bovine BS subjected to higher treatment temperatures. However, clinical data are insufficient. No distinctions were observed regarding ridge preservation, while slight advantages were noted for high-temperature treated particulate bovine BS in sinus floor elevation.
Subtle variances in both pre-clinical and clinical outcomes were observed in across various particulate bovine BS. Due to inadequate data, numerous considerations related to diverse particulate bovine BS, including peri-implant defects, must be more conclusive. Additional clinical studies are imperative to address these knowledge gaps effectively.
颗粒牛骨替代物（BS）常用于口腔再生。然而，需要更多的文献聚焦于各种颗粒牛 BS 之间的比较分析。本研究评估了不同颗粒牛 BS 在口腔再生中的临床前和临床数据。
通过筛选 PubMed 数据库进行叙述性综述。纳入的综述包括 2024 年前比较至少两种不同颗粒牛 BS 的临床前和临床研究。除了检查关于制造和处理过程、生物安全性、物理化学特性和移植物吸收的一般数据外，还特别关注评估与牙槽嵴保存、窦底提升、种植体周围缺损和利用颗粒牛 BS 进行各种形式的牙槽嵴增强相关的临床前和临床数据。
确定了颗粒牛 BS 制造过程中使用的各种处理温度（300 至 1250°C）和化学清洁步骤，这些步骤被认为具有生物安全性。颗粒牛 BS 的物理化学特性存在显著异质性，移植物吸收最小或可忽略不计。颗粒牛 BS 的颗粒和孔径以及孔隙率存在差异。临床前评估注意到，经较高处理温度处理的颗粒牛 BS 倾向于产生更好的结果。然而，临床数据不足。在牙槽嵴保存方面没有观察到差异，而在窦底提升方面，经高温处理的颗粒牛 BS 略有优势。
在不同颗粒牛 BS 之间观察到临床前和临床结果的细微差异。由于数据不足，必须对包括种植体周围缺损在内的多种颗粒牛 BS 进行更多的考虑。需要更多的临床研究来有效解决这些知识空白。
