Nyrop Kirsten A, Callahan Leigh F, Rini Christine, Altpeter Mary, Hackney Betsy, Schecher Arielle, Wilson Anne, Muss Hyman B
Division of Hematology/Oncology, CB 7305, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7305. Email:
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Prev Chronic Dis. 2015 Jun 11;12:E91. doi: 10.5888/pcd12.140535.
Adding aromatase inhibitors (AIs) to adjuvant treatment of postmenopausal women with hormone-receptor-positive breast cancer significantly reduces cancer recurrence. A common side effect of AIs is noninflammatory joint pain and stiffness (arthralgia) similar to arthritis symptoms. An evidence-based walking program developed by the Arthritis Foundation - Walk With Ease (WWE) - reduces arthritis-related joint symptoms. We hypothesized that WWE may also reduce AI-associated arthralgia. However, the potential for different barriers and facilitators to physical activity for these 2 patient populations suggested a need to adapt WWE before testing it with breast cancer survivors. We conducted qualitative research with 46 breast cancer survivors to explore program modification and inform the development of materials for an adapted program (Walk With Ease-Breast Cancer). Our process parallels the National Cancer Institute's Research-Tested Intervention Programs (RTIPs) guidelines for adapting evidence-based programs for cancer populations. Findings resulted in a customized 8-page brochure to supplement existing WWE materials.
在激素受体阳性的绝经后乳腺癌女性辅助治疗中添加芳香化酶抑制剂（AIs）可显著降低癌症复发率。AIs的一个常见副作用是与关节炎症状相似的非炎性关节疼痛和僵硬（关节痛）。关节炎基金会开发的一项循证步行计划——轻松步行（WWE）——可减轻与关节炎相关的关节症状。我们推测WWE也可能减轻与AI相关的关节痛。然而，这两类患者群体在身体活动方面存在不同的障碍和促进因素，这表明在对乳腺癌幸存者进行测试之前，需要对WWE进行调整。我们对46名乳腺癌幸存者进行了定性研究，以探索计划修改并为改编计划（轻松步行-乳腺癌）的材料开发提供信息。我们的过程与美国国立癌症研究所的研究测试干预计划（RTIPs）指南一致，该指南用于为癌症人群改编循证计划。研究结果形成了一份定制的8页手册，以补充现有的WWE材料。
