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Aromatase inhibitor associated arthralgia: the importance of oncology provider-patient communication about side effects and potential management through physical activity.

作者信息

Nyrop Kirsten A, Callahan Leigh F, Rini Christine, Altpeter Mary, Hackney Betsy, DePue Amy, Wilson Anne, Schechter Arielle, Muss Hyman B

机构信息

Division of Hematology and Oncology, School of Medicine, University of North Carolina at Chapel Hill, CB 7305, Chapel Hill, NC, 27599-7305, USA.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

出版信息

Support Care Cancer. 2016 Jun;24(6):2643-50. doi: 10.1007/s00520-015-3065-2. Epub 2016 Jan 12.


DOI:10.1007/s00520-015-3065-2
PMID:26757739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6467469/
Abstract

PURPOSE: Breast cancer survivors on aromatase inhibitors (AI) often experience side effects of joint pain, stiffness, or achiness (arthralgia). This study presents findings from a qualitative study of survivors on an AI regarding their knowledge of potential joint pain side effects and how both AI side effects and their management through moderate physical activity could be discussed during routine visits with their oncology provider. METHODS: Qualitative data from semi-structured interviews were content analyzed for emergent themes. Descriptive statistics summarize sample characteristics. RESULTS: Our sample included 36 survivors, mean age of 67 (range 46-87); 86 % Caucasian and 70 % had education beyond high school. AI experience are as follows: 64 % anastrozole/Arimidex, 48 % letrozole/Femara, and 31 % exemestane/Aromasin. Participants expressed interest in having more information about potential joint pain side effects when the AI was prescribed so they could understand their joint symptoms when they appeared or intensified. They were relieved to learn that their joint symptoms were not unusual or "in their head." Participants would have been especially motivated to try walking as a way to manage their joint pain if physical activity had been recommended by their oncologist. CONCLUSIONS: Breast cancer survivors who are prescribed an AI as part of their adjuvant treatment want ongoing communication with their oncology provider about the potential for joint pain side effects and how these symptoms may be managed through regular physical activity. The prescription of an AI presents a "teachable moment" for oncologists to recommend and encourage their patients to engage in regular physical activity.

摘要

相似文献

[1]
Aromatase inhibitor associated arthralgia: the importance of oncology provider-patient communication about side effects and potential management through physical activity.

Support Care Cancer. 2016-6

[2]
Feasibility and promise of a 6-week program to encourage physical activity and reduce joint symptoms among elderly breast cancer survivors on aromatase inhibitor therapy.

J Geriatr Oncol. 2013-12-28

[3]
Randomized Controlled Trial of a Home-Based Walking Program to Reduce Moderate to Severe Aromatase Inhibitor-Associated Arthralgia in Breast Cancer Survivors.

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[4]
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[5]
Adaptation of an Evidence-Based Arthritis Program for Breast Cancer Survivors on Aromatase Inhibitor Therapy Who Experience Joint Pain.

Prev Chronic Dis. 2015-6-11

[6]
Genetic and clinical predictors of arthralgia during letrozole or anastrozole therapy in breast cancer patients.

Breast Cancer Res Treat. 2020-9

[7]
Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors.

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[8]
Interventions for the Treatment of Aromatase Inhibitor-Associated Arthralgia in Breast Cancer Survivors: A Systematic Review and Meta-analysis.

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[9]
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[10]
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引用本文的文献

[1]
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JAMA Netw Open. 2025-5-1

[2]
Diosmetin Attenuates Painful Symptoms Caused by Antineoplastics Paclitaxel and Anastrozole in Mice.

Mol Neurobiol. 2025-4-14

[3]
Impact of a Physical Exercise and Health Education Program on Metabolic Syndrome and Quality of Life in Postmenopausal Breast Cancer Women Undergoing Adjuvant Treatment with Aromatase Inhibitors.

Medicina (Kaunas). 2024-11-18

[4]
Barriers and facilitators to physical activity in cancer survivors with pain: a systematic review.

Support Care Cancer. 2023-11-3

[5]
TRPV4 Activation and its Intracellular Modulation Mediated by Kinin Receptors Contribute to Painful Symptoms Induced by Anastrozole.

Mol Neurobiol. 2024-3

[6]
Kinin B and B Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms.

Pharmaceutics. 2023-4-3

[7]
Kinin B and B receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors.

Sci Rep. 2023-3-17

[8]
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Front Public Health. 2022

[9]
Pain and Spirituality Outcomes Among Women With Advanced Breast Cancer Participating in a Foot Reflexology Trial.

Oncol Nurs Forum. 2021-1-4

[10]
Exercise therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer.

Cochrane Database Syst Rev. 2020-1-29

本文引用的文献

[1]
Adaptation of an Evidence-Based Arthritis Program for Breast Cancer Survivors on Aromatase Inhibitor Therapy Who Experience Joint Pain.

Prev Chronic Dis. 2015-6-11

[2]
Musculoskeletal pain and health-related quality of life among breast cancer patients treated with aromatase inhibitors.

Support Care Cancer. 2015-2

[3]
Prospective examination of objectively assessed physical activity and sedentary time after breast cancer treatment: sitting on the crest of the teachable moment.

Cancer Epidemiol Biomarkers Prev. 2014-7

[4]
Late and long-term effects of breast cancer treatment and surveillance management for the general practitioner.

J Obstet Gynecol Neonatal Nurs. 2014

[5]
Feasibility and promise of a 6-week program to encourage physical activity and reduce joint symptoms among elderly breast cancer survivors on aromatase inhibitor therapy.

J Geriatr Oncol. 2013-12-28

[6]
Exercise intervention in breast cancer patients with aromatase inhibitor-associated arthralgia: a pilot study.

Eur J Cancer Care (Engl). 2014-7

[7]
Tai chi for well-being of breast cancer survivors with aromatase inhibitor-associated arthralgias: a feasibility study.

Altern Ther Health Med. 2013

[8]
Achievement of exercise objectives and satisfaction with the walk with ease program-group and self-directed participants.

Am J Health Promot. 2014

[9]
Relationships between three beliefs as barriers to symptom management and quality of life in older breast cancer survivors.

Oncol Nurs Forum. 2013-5-1

[10]
Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort.

Cancer. 2013-4-10

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