Dimenäs E S, Wiklund I K, Dahlöf C G, Lindvall K G, Olofsson B K, De Faire U H
Research Laboratories, AB Hässle, Mölndal, Sweden.
J Hypertens. 1989 Nov;7(11):885-90. doi: 10.1097/00004872-198911000-00006.
In this study, previously untreated subjects were randomly recruited from a blood pressure screening programme. After repeated measurement of blood pressure levels, the subjects were divided into three major groups: normotensives (n = 95), borderline hypertensives (n = 69) and hypertensives (n = 30). Three self-administered standardized questionnaires were used to measure different aspects of subjective well-being and symptoms: the Nottingham Health Profile (NHP), the Subjective Symptoms Assessment Profile (SSAP) and the Minor Symptoms Evaluation Profile (MSEP). The results indicate gradual differences between the three groups, the most pronounced symptoms being seen among the hypertensives. Statistically significant differences were found for cardiac and gastrointestinal symptoms as well as for emotional reactions, home life, social life, sex life and sleep. The differences in well-being and subjective symptoms noted between the groups are important in the evaluation of new antihypertensive agents. Self-administered questionnaires of the type used in this study could also be valuable in identifying symptoms and disturbances in subjective well-being related to the antihypertensive medication per se.
在本研究中，从未接受过治疗的受试者是从一项血压筛查项目中随机招募的。在反复测量血压水平后，受试者被分为三大组：血压正常者（n = 95）、临界高血压患者（n = 69）和高血压患者（n = 30）。使用三份自我管理的标准化问卷来测量主观幸福感和症状的不同方面：诺丁汉健康量表（NHP）、主观症状评估量表（SSAP）和轻微症状评估量表（MSEP）。结果表明三组之间存在渐进差异，高血压患者中出现的症状最为明显。在心脏和胃肠道症状以及情绪反应、家庭生活、社交生活、性生活和睡眠方面发现了具有统计学意义的差异。各组之间在幸福感和主观症状方面的差异在评估新型抗高血压药物时很重要。本研究中使用的此类自我管理问卷在识别与抗高血压药物本身相关的主观幸福感症状和干扰方面也可能很有价值。
