Noda Yoshifumi, Kanematsu Masayuki, Goshima Satoshi, Horikawa Yukio, Takeda Jun, Kondo Hiroshi, Watanabe Haruo, Kawada Hiroshi, Kawai Nobuyuki, Tanahashi Yukichi, Bae Kyongtae T
Department of Radiology, Gifu University Hospital, Gifu, Japan.
Department of Radiology Services, Gifu University Hospital, Gifu, Japan.
J Magn Reson Imaging. 2016 Jan;43(1):159-65. doi: 10.1002/jmri.24982. Epub 2015 Jun 12.
To evaluate the feasibility of diffusion kurtosis (DK) imaging of the pancreas for the assessment of hemoglobin (Hb) A1c values.
Our Institutional Review Board approved this prospective study and written informed consent was obtained. In all, 102 consecutive patients with suspected pancreatic disease underwent magnetic resonance imaging (MRI), including DK imaging. Patients were classified into three groups according to American Diabetes Association criteria: HbA1c < 5.7% (group 1), 5.7% ≤ HbA1c < 6.5% (group 2), and HbA1c ≥ 6.5% (group 3). Mean kurtosis (MK) and apparent diffusion coefficient (ADC) of pancreatic parenchyma were computed. MRI measurements and HbA1c values were then compared.
HbA1c values positively correlated with MK (r = 0.66, P < 0.0001). Group 3 was significantly (P < 0.05) higher (P < 0.05) in MK than groups 1 and 2. The sensitivity, specificity, and area under the ROC curve of the MK for the detection of group 3 were 90%, 88%, and 0.92, respectively.
The MK measurement on DK imaging of the pancreas could be a potential biomarker for assessing HbA1c level.
评估胰腺扩散峰度（DK）成像用于评估糖化血红蛋白（Hb）A1c值的可行性。
本前瞻性研究获我院机构审查委员会批准，并获得书面知情同意书。共有102例连续的疑似胰腺疾病患者接受了磁共振成像（MRI）检查，包括DK成像。根据美国糖尿病协会标准，将患者分为三组：HbA1c<5.7%（第1组），5.7%≤HbA1c<6.5%（第2组），以及HbA1c≥6.5%（第3组）。计算胰腺实质的平均峰度（MK）和表观扩散系数（ADC）。然后比较MRI测量值和HbA1c值。
HbA1c值与MK呈正相关（r = 0.66，P < 0.0001）。第3组的MK显著高于第1组和第2组（P < 0.05）。MK检测第3组的敏感性、特异性和ROC曲线下面积分别为90%、88%和0.92。
胰腺DK成像上的MK测量可能是评估HbA1c水平的潜在生物标志物。
