Noda Yoshifumi, Goshima Satoshi, Tanaka Kaori, Osada Shinji, Tomita Hiroyuki, Hara Akira, Horikawa Yukio, Takeda Jun, Kajita Kimihiro, Watanabe Haruo, Kawada Hiroshi, Kawai Nobuyuki, Kanematsu Masayuki, Bae Kyongtae T
Department of Radiology, Gifu University Hospital, Gifu, Japan.
Department of Surgical Oncology, Gifu University Hospital, Gifu, Japan.
J Magn Reson Imaging. 2016 Mar;43(3):680-7. doi: 10.1002/jmri.25019. Epub 2015 Jul 22.
To evaluate the diagnostic performance of noncontrast-enhanced magnetic resonance imaging (MRI) to grade pancreatic fibrosis and to assess hemoglobin (Hb) A1c values.
Twenty-nine consecutive patients with pancreatic or biliary malignancy who underwent pancreatectomy were evaluated. Patients were classified into three groups: HbA1c < 5.7 (group 1), 5.7 ≤ HbA1c < 6.5 (group 2), and HbA1c ≥ 6.5 (group 3). MRI of the pancreas was performed using a 1.5T MR system. The pancreas-to-muscle signal intensity ratio (SIR) on in- and opposed-phase T1 -, T2 -, and diffusion-weighted images, as well as the apparent diffusion coefficient were calculated. MRI measurements, degrees of pancreatic fibrosis, and HbA1c values were compared using multiple regression analysis and Kruskal-Wallis test.
The pancreatic fibrosis grade was negatively correlated with the SIR on in-phase T1 -weighted images (r = -0.67, P = 0.0002). The pancreatic fibrosis grade and HbA1c value were negatively correlated with the SIR on opposed-phase T1 -weighted images (r = -0.47, P = 0.019 and r = -0.51, P = 0.0089, respectively). SIRs on in- and opposed-phase T1 -weighted images were significantly lower in group 3 than in groups 1 and 2 (P < 0.05).
The pancreas-to-muscle SIRs on in- and opposed-phase T1 -weighted images could be a potential biomarker for pancreatic fibrosis and elevated HbA1c values.
评估非增强磁共振成像（MRI）对胰腺纤维化分级及评估糖化血红蛋白（Hb）A1c值的诊断性能。
对29例连续接受胰腺切除术的胰腺或胆道恶性肿瘤患者进行评估。患者分为三组：HbA1c＜5.7（第1组）、5.7≤HbA1c＜6.5（第2组）和HbA1c≥6.5（第3组）。使用1.5T MR系统对胰腺进行MRI检查。计算同相位和反相位T1加权、T2加权及扩散加权图像上的胰腺与肌肉信号强度比（SIR）以及表观扩散系数。采用多元回归分析和Kruskal-Wallis检验比较MRI测量值、胰腺纤维化程度和HbA1c值。
胰腺纤维化分级与同相位T1加权图像上的SIR呈负相关（r = -0.67，P = 0.0002）。胰腺纤维化分级和HbA1c值与反相位T1加权图像上的SIR呈负相关（分别为r = -0.47，P = 0.019和r = -0.51，P = 0.0089）。第3组同相位和反相位T1加权图像上的SIR显著低于第1组和第2组（P＜0.05）。
同相位和反相位T1加权图像上的胰腺与肌肉SIR可能是胰腺纤维化和HbA1c值升高的潜在生物标志物。
