Chikaishi T, Tanemura H, Saji S, Kato K, Shimokawa K
2nd Dept. of Surgery, Gifu Univ. School of Med.
Gan No Rinsho. 1989 Dec;35(15):1739-44.
A microspectrophotometric analysis of the DNA content has been performed on 9 advanced recurrent gastric cancer patients with measurable lesions, who has either been treated by CDDP alone or with other chemotherapeutics during a three-year period since, 1984. Histograms of the DNA content were classified into four ploidy patterns. All of the 4 responder cases (CR, PR, MR) showed type, IV, although only one of 5 non-responder cases revealed the same typing. In one of the two CR cases the DNA ploidy pattern, which was examined before and after the therapy, changed from type IV to type II. Thus it appears that an analysis of the DNA content may be useful in evaluating the effectiveness of different chemotherapies.
对9例有可测量病灶的晚期复发性胃癌患者进行了DNA含量的显微分光光度分析，这些患者自1984年以来的三年期间，要么单独接受顺铂治疗，要么接受其他化疗。DNA含量的直方图被分为四种倍体模式。所有4例有反应的病例（完全缓解、部分缓解、病情稳定）均显示为IV型，尽管5例无反应的病例中只有1例显示相同的类型。在2例完全缓解的病例中，有1例在治疗前后检查的DNA倍体模式从IV型变为II型。因此，DNA含量分析似乎有助于评估不同化疗的效果。
