Satoh M, Takeda T, Toyama H, Nakajima K, Ishikawa N, Akisada M
Kaku Igaku. 1989 May;26(5):581-9.
Single photon emission computed tomography of the brain and dynamic scintigraphy of the lung and liver with N-isopropyl-p-[123I]iodoamphetamine (IMP) were performed in 21 patients with and without cerebrovascular diseases to determine the relationship between IMP accumulation in the brain and its dynamics in other organs. The D/E ratios of the lung, liver and brain were calculated dividing the counts of the delayed image by that of the early image. The brain D/E ratio in the normal hemisphere was well correlated with the lung D/E ratio. So cases which showed more rapid lung washout tended to washout faster from the brain. We thought that this fact was affected by the systemic circulation. And the values of the brain D/E ratio of the cerebrovascular disease group were larger than that of the non-cerebrovascular disease group. This suggest the frequent existence of arteriosclerotic changes in patients of the cerebrovascular disease. Because the local brain washout was depended on the amount of the cerebral blood flow there. On the other hand, the lung D/E ratio was inversely correlated with the liver D/E ratio. In other words, more washout from the lung caused more accumulation of IMP in the liver. Also the brain D/E ratio was inversely correlated with the liver D/E ratio. In conclusion, there was a close relationship between IMP dynamics in the brain and that in other organs.
对21例有或没有脑血管疾病的患者进行了脑单光子发射计算机断层扫描以及用N-异丙基-p-[123I]碘安非他明（IMP）进行肺和肝脏的动态闪烁扫描，以确定IMP在脑内的蓄积与其在其他器官中的动态变化之间的关系。通过将延迟图像的计数除以早期图像的计数来计算肺、肝脏和脑的D/E比值。正常半球的脑D/E比值与肺D/E比值密切相关。因此，肺清除较快的病例往往脑清除也较快。我们认为这一事实受体循环的影响。而且脑血管疾病组的脑D/E比值高于非脑血管疾病组。这表明脑血管疾病患者中经常存在动脉硬化改变。因为局部脑清除取决于脑血流量。另一方面，肺D/E比值与肝脏D/E比值呈负相关。换句话说，肺清除越多，IMP在肝脏中的蓄积就越多。脑D/E比值也与肝脏D/E比值呈负相关。总之，IMP在脑内的动态变化与在其他器官中的动态变化之间存在密切关系。
