Tomimoto H, Hayashi M, Kawahara Y, Kiyokawa F, Fukunaga M
Department of Internal Medicine and Kurashiki Central Hospital, Japan.
Radioisotopes. 1987 Dec;36(12):650-2. doi: 10.3769/radioisotopes.36.12_650.
Semi-quantitative method of N-isopropyl-(123I)-p-iodoamphetamine (123I-IMP) accumulation in cerebrum by using 123I-IMP SPECT was tried. Ratio of counts in whole cerebrum to those in normal cerebellum was calculated, and this accumulation is defined as cerebrum to cerebellum accumulation ratio. In group of patients with dementia or patients who were remaining in bed, significantly low accumulation ratio was observed, while in "normal" group, no differences in sex and aging were observed. Calculation of cerebrum to cerebellum accumulation ratio was concluded as a useful method of evaluating the accumulation of 123I-IMP in cerebrum.
尝试采用123I-异丙基-p-碘安非他明（123I-IMP）单光子发射计算机断层扫描（SPECT）半定量法测定大脑中123I-IMP的蓄积情况。计算全脑计数与正常小脑计数的比值，该蓄积定义为脑小脑蓄积比。在痴呆患者组或卧床患者组中，观察到蓄积比显著降低，而在“正常”组中，未观察到性别和年龄差异。得出脑小脑蓄积比的计算是评估大脑中123I-IMP蓄积的一种有用方法。
