Mao Bei, Lu Hai-Wen, Li Man-Hui, Fan Li-Chao, Yang Jia-Wei, Miao Xia-Yi, Xu Jin-Fu
1] Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, China [2] Soochow University, Suzhou, China.
Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai, China.
Sci Rep. 2015 Jun 16;5:10961. doi: 10.1038/srep10961.
Bronchiectasis is prevalent in patients with COPD. The objective of this study was to assess the clinical characteristics and prognostic value of bronchiectasis in patients with COPD in China. Data from patients diagnosed with COPD at the Shanghai Pulmonary Hospital between January 2009 and December 2013 were retrospectively collected and analyzed. SPSS statistical software was used to analyze the data. Data from 896 patients with COPD were analyzed. Bronchiectasis was present in 311 patients. The isolation of pseudomonas aeruginosa (PA) from sputum was the variable most significantly associated with the presence of bronchiectasis in patients with COPD (hazard ratio (HR), 2.93; 95% confidence interval (CI), 1.35-6.37; P = 0.007). During follow-up (median of 21 months; interquartile range: 10-39 months), there were 75 deaths, of which 39 were in the bronchiectasis group. The presence of bronchiectasis (HR, 1.77; 95% CI, 1.02-3.08; P = 0.043) was associated with an increase in all-cause mortality in patients with COPD. These results suggest that bronchiectasis in patients with COPD was associated with the isolation of PA from the sputum. Bronchiectasis was an independent risk factor for all-cause mortality in patients with COPD.
支气管扩张在慢性阻塞性肺疾病（COPD）患者中很常见。本研究的目的是评估中国COPD患者中支气管扩张的临床特征和预后价值。回顾性收集并分析了2009年1月至2013年12月期间在上海肺科医院被诊断为COPD的患者的数据。使用SPSS统计软件分析数据。分析了896例COPD患者的数据。其中311例患者存在支气管扩张。痰中分离出铜绿假单胞菌（PA）是COPD患者中与支气管扩张存在最显著相关的变量（风险比（HR），2.93；95%置信区间（CI），1.35 - 6.37；P = 0.007）。在随访期间（中位时间为21个月；四分位间距：10 - 39个月），有75例死亡，其中39例在支气管扩张组。支气管扩张的存在（HR，1.77；95% CI，1.02 - 3.08；P = 0.043）与COPD患者全因死亡率增加相关。这些结果表明，COPD患者中的支气管扩张与痰中PA的分离有关。支气管扩张是COPD患者全因死亡的独立危险因素。
