采用颗粒电子顺磁共振、磁共振成像和电感耦合等离子体质谱法研究 SPION 的生物分布和药代动力学。
Biodistribution and pharmacokinetic studies of SPION using particle electron paramagnetic resonance, MRI and ICP-MS.
机构信息
School of Pharmacy & Pharmaceutical Sciences, Dublin, Ireland.
Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
出版信息
Nanomedicine (Lond). 2015;10(11):1751-60. doi: 10.2217/nnm.15.22.
AIM
Superparamagnetic iron oxide nanoparticles (SPIONs) may play an important role in nanomedicine by serving as drug carriers and imaging agents. In this study, we present the biodistribution and pharmacokinetic properties of SPIONs using a new detection method, particle electron paramagnetic resonance (pEPR).
MATERIALS & METHODS: The pEPR technique is based on a low-field and low-frequency electron paramagnetic resonance. pEPR was compared with inductively coupled plasma mass spectrometry and MRI, in in vitro and in vivo.
RESULTS
The pEPR, inductively coupled plasma mass spectrometry and MRI results showed a good correlation between the techniques.
CONCLUSION
The results indicate that pEPR can be used to detect SPIONs in both preclinical and clinical studies.
目的
超顺磁性氧化铁纳米粒子（SPIONs）可作为药物载体和成像剂，在纳米医学中发挥重要作用。本研究采用一种新的检测方法——颗粒电子顺磁共振（pEPR），研究了 SPIONs 的体内分布和药代动力学特性。
材料与方法
pEPR 技术基于低场低频电子顺磁共振，将其与体外和体内的电感耦合等离子体质谱法和 MRI 进行了比较。
结果
pEPR、电感耦合等离子体质谱法和 MRI 的结果表明，这些技术之间具有良好的相关性。
结论
结果表明，pEPR 可用于临床前和临床研究中 SPIONs 的检测。
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