Park Mijung, Verhoeven Josine E, Cuijpers Pim, Reynolds Charles F, Penninx Brenda W J H
Department of Health and Community Systems, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
PLoS One. 2015 Jun 17;10(6):e0128460. doi: 10.1371/journal.pone.0128460. eCollection 2015.
Strong evidence supports that living in disadvantaged neighborhoods has direct unfavorable impact on mental and physical health. However, whether it also has direct impact on cellular health is largely unknown. Thus we examined whether neighborhood quality was associated with leukocyte telomere length, an indicator of cellular aging.
In May 2014, we extracted and analyzed baseline data from the Netherlands Study of Depression and Anxiety (NESDA), a large epidemiological study of individuals age between 18-65 years (n=2902). Telomere length was determined using quantitative polymerase chain reaction. Neighborhood quality was assessed using modified measures of perceived neighborhood disorder, fear of crime, and noise. We used multivariable linear regression models to examine association between perceived neighborhood quality and telomere length with comprehensive adjustment for individual and community characteristics related to socioeconomic and demographic status, urbanization level, mental and physical health, and lifestyle.
Compared to individuals who reported good neighborhood quality, the mean telomere length of those who reported moderate neighborhood quality was approximately 69 base pair shorter (β =-69.33, 95% CI: -119.49, -19.17, p= 0.007), and that of those who reported poor neighborhood quality were 174 base pair shorter (β =-173.80, 95% CI: -298.80, -49.01, p=0.006). For illustrative purposes, one could extrapolate these outcomes to 8.7 and 11.9 years in chronological age, respectively.
We have established an association between perceived neighborhood quality and cellular aging over and above a range of individual attributes. Biological aging processes may be impacted by socioeconomic milieu.
有力证据表明，生活在条件较差的社区对身心健康有直接的不利影响。然而，其是否对细胞健康也有直接影响在很大程度上尚不清楚。因此，我们研究了社区质量是否与白细胞端粒长度相关，白细胞端粒长度是细胞衰老的一个指标。
2014年5月，我们从荷兰抑郁与焦虑研究（NESDA）中提取并分析了基线数据，NESDA是一项针对18至65岁个体的大型流行病学研究（n = 2902）。使用定量聚合酶链反应测定端粒长度。社区质量通过对感知到的社区混乱、对犯罪的恐惧和噪音的改良测量方法进行评估。我们使用多变量线性回归模型，对与社会经济和人口状况、城市化水平、身心健康及生活方式相关的个体和社区特征进行全面调整，以研究感知到的社区质量与端粒长度之间的关联。
与报告社区质量良好的个体相比，报告社区质量中等的个体的平均端粒长度约短69个碱基对（β = -69.33，95%CI：-119.49，-19.17，p = 0.007），报告社区质量差的个体的平均端粒长度短174个碱基对（β = -173.80，95%CI：-298.80，-49.01，p = 0.006）。为便于说明，可将这些结果分别外推至按时间顺序计算的年龄增长8.7岁和11.9岁。
我们已经确定，在一系列个体属性之外，感知到的社区质量与细胞衰老之间存在关联。生物衰老过程可能受到社会经济环境的影响。
