Fan F, Zou Y, Tian H, Zhang Y, Zhang J, Ma X, Meng Y, Yue Y, Liu K, Dart A M
Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
Baker IDI Heart and Diabetes, Institute & Department of Cardiovascular Medicine, The Alfred, Melbourne, Victoria, Australia.
J Hum Hypertens. 2016 Mar;30(3):171-6. doi: 10.1038/jhh.2015.64. Epub 2015 Jun 18.
Psychological disturbances, including anxiety and depression, are common during human pregnancy. Our objective was to determine whether these maternal disturbances influence cardiovascular responses of the offspring. The psychological status of 231 pregnant women was determined. Offspring (216) of these women were subsequently exposed to a video challenge stress when aged 7-9 years. Heart rate (HR) and blood pressure (BP) of the children were determined at rest, in response to video stress and during subsequent recovery. Children's resting and stress-induced increases in HR (bpm), systolic (SBP, mm Hg) and diastolic (DBP, mm Hg) BP were all greater in children whose mothers reported anxiety during pregnancy. Values (mean±s.d.) for resting HR, SBP and DBP were 75.15±5.87, 95.37±2.72 and 66.39±4.74 for children whose mothers reported no anxiety and an average of 81.62±6.71, 97.26±2.90 and 68.86±2.82 for children whose mothers reported anxiety at any level. Respective values for stress-induced increments in HR, SBP and DBP were 14.83.±2.14, 16.41±1.97 and 12.72±2.69 for children whose mothers reported no anxiety and 17.95±3.46, 18.74±2.46 and 14.86±2.02 for children whose mothers reported any level of anxiety. Effects of maternal depression were less consistent. The effects of maternal anxiety remained in multivariate analyses, which also included children's birth weight. The results indicate a long-term influence of maternal psychological status during pregnancy on the cardiovascular responses to stress among offspring. These effects may contribute to prenatal influences on subsequent health of the offspring.
心理障碍，包括焦虑和抑郁，在人类孕期很常见。我们的目的是确定这些母体障碍是否会影响后代的心血管反应。我们测定了231名孕妇的心理状态。这些女性的后代（216名）在7至9岁时随后接受了视频挑战应激测试。测定了孩子们在静息状态下、对视频应激的反应以及随后恢复过程中的心率（HR）和血压（BP）。母亲在孕期报告有焦虑情绪的孩子，其静息心率、收缩压（SBP，毫米汞柱）和舒张压（DBP，毫米汞柱）以及应激引起的这些指标的升高幅度均更大。母亲报告无焦虑的孩子，其静息心率、SBP和DBP的值（均值±标准差）分别为75.15±5.87、95.37±2.72和66.39±4.74，而母亲报告有任何程度焦虑的孩子，这些值的平均值分别为81.62±6.71、97.26±2.90和68.86±2.82。母亲报告无焦虑的孩子，应激引起的HR、SBP和DBP升高幅度的相应值分别为14.83±2.14、16.41±1.97和12.72±2.69，而母亲报告有任何程度焦虑的孩子，这些值分别为17.95±3.46、18.74±2.46和14.86±2.02。母体抑郁的影响不太一致。母体焦虑的影响在多变量分析中仍然存在，多变量分析还包括孩子的出生体重。结果表明孕期母体心理状态对后代心血管应激反应有长期影响。这些影响可能有助于产前因素对后代后续健康产生影响。
