2'-脱氧-6,2'-亚甲基嘧啶核苷的合成及嘧啶C-环核苷的光学性质
Synthesis of 2'-deoxy-6,2'-methano-pyrimidine nucleosides and optical properties of pyrimidine C-cyclonucleosides.
作者信息
Yoshimura Y, Matsuda A, Ueda T
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
出版信息
Nucleic Acids Symp Ser. 1989(21):79-80.
PMID:2608488
Abstract
2'-Deoxy-6,2'-methano derivatives of uridine, cytidine, and 4-thiouridine were synthesized by the Peterson olefination of a ketosugar with a pyrimidine followed by an intramolecular glycosylation reaction. CD-spectra of these cyclonucleosides together with other pyrimidine C-cyclonucleosides were given.
摘要
通过酮糖与嘧啶的彼得森烯烃化反应，随后进行分子内糖基化反应，合成了尿苷、胞苷和4-硫尿苷的2'-脱氧-6,2'-亚甲基衍生物。给出了这些环核苷以及其他嘧啶C-环核苷的圆二色光谱。
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