Soto Robert J, Schoenfisch Mark H
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Diabetes Sci Technol. 2015 Jun 17;9(5):978-84. doi: 10.1177/1932296815590628.
The utility of continuous glucose monitoring devices remains limited by an obstinate foreign body response (FBR) that degrades the analytical performance of the in vivo sensor. A number of novel materials that resist or delay the FBR have been proposed as outer, tissue-contacting glucose sensor membranes as a strategy to improve sensor accuracy. Traditionally, researchers have examined the ability of a material to minimize the host response by assessing adsorbed cell morphology and tissue histology. However, these techniques do not adequately predict in vivo glucose sensor function, necessitating sensor performance evaluation in a relevant animal model prior to human testing. Herein, the effects of critical experimental parameters, including the animal model and data processing methods, on the reliability and usefulness of preclinical sensor performance data are considered.
连续血糖监测设备的效用仍然受到顽固的异物反应（FBR）的限制，这种反应会降低体内传感器的分析性能。一些能够抵抗或延缓异物反应的新型材料已被提议用作与组织接触的外部葡萄糖传感器膜，以此作为提高传感器准确性的策略。传统上，研究人员通过评估吸附细胞形态和组织组织学来检验材料将宿主反应降至最低的能力。然而，这些技术无法充分预测体内葡萄糖传感器的功能，因此在人体测试之前，需要在相关动物模型中评估传感器性能。在此，我们考虑了包括动物模型和数据处理方法在内的关键实验参数对临床前传感器性能数据的可靠性和实用性的影响。
