Chung Kyung-Sook, An Hyo-Jin, Cheon Se-Yun, Kwon Ki-Rok, Lee Kwang-Ho
Department of Pharmacology, College of Oriental Medicine, Sangji University, Wonju-si, Gangwon-do 220-702, Republic of Korea.
Ginseng&Venom, Sngji University, Wonju-si, Gangwon-do 220-702, Republic of Korea.
Exp Biol Med (Maywood). 2015 Dec;240(12):1656-63. doi: 10.1177/1535370215590823. Epub 2015 Jun 17.
Benign prostatic hyperplasia (BPH), which is a common disorder in aging men, involves inflammation that is associated with an imbalance between cell proliferation and cell death. Because current BPH drug treatments have undesirable side effects, the development of well-tolerated and effective alternative medicines to treat BPH is of interest. Bee venom (BV) has been used in traditional medicine to treat conditions, such as arthritis and rheumatism, and pain. Although inflammation has been associated with BPH and BV has strong anti-inflammatory effects, the effects of BV on BPH are not fully understood. Therefore, in this study, we evaluated the efficacy of BV against testosterone-induced BPH in rats. BV decreased prostate weight compared to the untreated group. In addition, BV suppressed serum dihydrotestosterone concentration levels and the levels of proliferating cell nuclear antigen in the histological analysis. Furthermore, BV significantly decreased the levels of the apoptotic suppressors, Bcl-2 and Bcl-xL, and increased the levels of the proapoptotic factors, Bax and caspase-3 activation. These results suggested that BV suppressed the development of BPH and has good potential as a treatment for BPH.
良性前列腺增生（BPH）是老年男性的常见疾病，涉及与细胞增殖和细胞死亡失衡相关的炎症。由于目前的BPH药物治疗存在不良副作用，因此开发耐受性良好且有效的替代药物来治疗BPH备受关注。蜂毒（BV）已被用于传统医学治疗诸如关节炎、风湿病和疼痛等病症。尽管炎症与BPH有关，且BV具有强大的抗炎作用，但BV对BPH的影响尚未完全明确。因此，在本研究中，我们评估了BV对大鼠睾酮诱导的BPH的疗效。与未治疗组相比，BV降低了前列腺重量。此外，在组织学分析中，BV抑制了血清双氢睾酮浓度水平以及增殖细胞核抗原水平。此外，BV显著降低了凋亡抑制因子Bcl-2和Bcl-xL的水平，并增加了促凋亡因子Bax和caspase-3激活的水平。这些结果表明，BV抑制了BPH的发展，具有作为BPH治疗药物的良好潜力。
