Dos Santos Ariane Teixeira, Cruz Gabriela Silva, Baptista Gandhi Rádis
Graduate Program in Pharmaceutical Sciences, School of Pharmacy, Dentistry and Nursing, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Laboratory of Biochemistry and Biotechnology, Institute for Marine Sciences, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
J Venom Anim Toxins Incl Trop Dis. 2021 Oct 22;27:e20200152. doi: 10.1590/1678-9199-JVATITD-2020-0152. eCollection 2021.
Peptides obtained from different animal species have gained importance recently due to research that aims to develop biopharmaceuticals with therapeutic potential. In this sense, arthropod venoms have drawn attention, not only because of their toxicity but mainly for the search for molecules with various bioactivities, including anti-inflammatory activity. The purpose of the present study is to gather data available in the literature on new peptides derived from arthropod species with anti-inflammatory potential. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Studies on peptides from arthropods that display anti-inflammatory activity were retrieved from PubMed, Scopus, Web of Science, and Google Scholar databases. The bibliographic research started in 2020 and searched papers without a limit on the publication date. The articles were analyzed using a search string containing the following terms: "Peptides" and "Anti-inflammatory", in combinations such as "Ant", "Bee", "Wasp", "Crab", "Shrimp", "Scorpion", "Spider", "Tick" and "Centipedes". Besides, a search was carried out in the databases with the terms: "Peptides", "Antitumor", or "Anticancer", and "Arthropods". Articles that met the inclusion and exclusion criteria totalized 171, and these served for data extraction. Additionally, the present review included anti-inflammatory peptides with anticancer properties. Peptides with confirmed anti-inflammatory activity were from insects (ants, bees, and wasps), crustaceans (shrimp and crabs), arachnids (scorpions, spiders, and ticks), and centipedes. These arthropod peptides act mainly by decreasing pro-inflammatory cytokines as analyzed and . Some showed significant antineoplastic activity, working in essential cellular pathways against malignant neoplasms.
由于旨在开发具有治疗潜力的生物制药的研究，近年来从不同动物物种获得的肽变得越来越重要。从这个意义上说，节肢动物毒液引起了关注，这不仅是因为它们的毒性，更主要的是因为要寻找具有多种生物活性的分子，包括抗炎活性。本研究的目的是收集文献中有关源自节肢动物物种且具有抗炎潜力的新肽的可用数据。本系统评价遵循系统评价和Meta分析的首选报告项目（PRISMA）指南。从PubMed、Scopus、科学网和谷歌学术数据库中检索有关显示抗炎活性的节肢动物肽的研究。文献研究始于2020年，搜索的论文不限制出版日期。使用包含以下术语的搜索字符串对文章进行分析：“肽”和“抗炎”，组合形式如“蚂蚁”、“蜜蜂”、“黄蜂”、“螃蟹”、“虾”、“蝎子”、“蜘蛛”、“蜱”和“蜈蚣”。此外，还在数据库中使用“肽”、“抗肿瘤”或“抗癌”以及“节肢动物”等术语进行了搜索。符合纳入和排除标准的文章共有171篇，这些文章用于数据提取。此外，本综述还包括具有抗癌特性的抗炎肽。具有确认抗炎活性的肽来自昆虫（蚂蚁、蜜蜂和黄蜂）、甲壳类动物（虾和螃蟹）、蛛形纲动物（蝎子、蜘蛛和蜱）和蜈蚣。如分析所示，这些节肢动物肽主要通过减少促炎细胞因子发挥作用。一些肽显示出显著的抗肿瘤活性，作用于对抗恶性肿瘤的关键细胞途径。
