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TCF4基因多态性与富克斯角膜内皮营养不良的关联：一项荟萃分析。

Association of TCF4 polymorphisms and Fuchs' endothelial dystrophy: a meta-analysis.

作者信息

Li Dan, Peng XiaoYan, Sun HuiYu

机构信息

Beijng Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing, 100730, China.

Department of Ophthalmology, Beijng di tan Hospital, Capital Medical University, Beijing, China.

出版信息

BMC Ophthalmol. 2015 Jun 19;15:61. doi: 10.1186/s12886-015-0055-6.

DOI:10.1186/s12886-015-0055-6
PMID:26087656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4474332/
Abstract

BACKGROUND

Studies investigating the associations between transcription factor 4 (TCF4) genetic polymorphisms and Fuchs' endothelial dystrophy (FED) have reported controversial results. Therefore, this meta-analysis aims to clarify the effects of TCF4 polymorphisms on FED risk.

METHODS

A meta-analysis was conducted to assess the association between four single nucleotide polymorphisms (SNPs) inTCF4 and the risk of FED. Relevant studies were selected through an extensive search of PubMed, EMBASE, and the Web of Science databases. Pooled odds ratio (OR) and 95 % confidence interval (CI) were calculated using the random-effects model.

RESULTS

Thirteen studies were included in this systematic review and meta-analysis. The pooled results showed that there was a strong positive association between the TCF4 rs613872 polymorphism and FED risk in all the genetic models tested (G allele vs. T allele: OR = 4.19, 95 % CI = 3.53-4.97; GG vs.

GT/TT: OR = 4.27, 95 % CI = 2.54-7.19; GG/GT vs. TT: OR = 6.29, 95 % CI = 4.23-8.93; GG VS. TT: OR = 10.64, 95 % CI = 5.28-21.41; GT VS. TT: OR = 6.08, 95 % CI = 4.28-8.64). Statistic evidence was also detected for a significant association between three other SNPs and the risk of FED.

CONCLUSIONS

This meta-analysis suggested a genetic association between four TCF4 polymorphisms (rs613872, rs2286812, rs17595731, and rs9954153) and the risk of FED.

摘要

背景

关于转录因子4（TCF4）基因多态性与富克斯内皮营养不良（FED）之间关联的研究报告了相互矛盾的结果。因此，本荟萃分析旨在阐明TCF4基因多态性对FED风险的影响。

方法

进行荟萃分析以评估TCF4中四个单核苷酸多态性（SNP）与FED风险之间的关联。通过广泛检索PubMed、EMBASE和Web of Science数据库来选择相关研究。使用随机效应模型计算合并优势比（OR）和95%置信区间（CI）。

结果

本系统评价和荟萃分析纳入了13项研究。汇总结果显示，在所有测试的遗传模型中，TCF4 rs613872多态性与FED风险之间存在强正相关（G等位基因与T等位基因：OR = 4.19，95% CI = 3.53 - 4.97；GG与GT/TT：OR = 4.27，95% CI = 2.54 - 7.19；GG/GT与TT：OR = 6.29，95% CI = 4.23 - 8.93；GG与TT：OR = 10.64，95% CI = 5.28 - 21.41；GT与TT：OR = 6.08，95% CI = 4.28 - 8.64）。还检测到其他三个SNP与FED风险之间存在显著关联的统计学证据。

结论

本荟萃分析表明，四个TCF4多态性（rs613872、rs2286812、rs17595731和rs9954153）与FED风险之间存在遗传关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3349/4474332/379dbfabe2fb/12886_2015_55_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3349/4474332/1597bade5902/12886_2015_55_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3349/4474332/917ece2ba8e5/12886_2015_55_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3349/4474332/379dbfabe2fb/12886_2015_55_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3349/4474332/1597bade5902/12886_2015_55_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3349/4474332/917ece2ba8e5/12886_2015_55_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3349/4474332/379dbfabe2fb/12886_2015_55_Fig3_HTML.jpg

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