CX3CR1基因多态性（V249I和T280M）与年龄相关性黄斑变性的关联：一项荟萃分析。

Association of CX3CR1 (V249I and T280M) polymorphisms with age-related macular degeneration: a meta-analysis.

作者信息

Li Dan, Peng XiaoYan, Sun HuiYu

机构信息

Department of Ophthalmology, Beijing Di Tan Hospital, Capital Medical University, Beijing, China.

Beijng Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Hospital.

出版信息

Can J Ophthalmol. 2015 Dec;50(6):451-60. doi: 10.1016/j.jcjo.2015.08.010.

DOI:10.1016/j.jcjo.2015.08.010

PMID:26651305

Abstract

OBJECTIVE

Studies investigating the associations between CX3CR1 genetic polymorphisms and age-related macular degeneration (AMD) have reported controversial results. Therefore, this meta-analysis aims to clarify the effects of CX3CR1 T280M and V249I polymorphisms on AMD risk.

DESIGN

Meta-analysis.

PARTICIPANTS

Results from six studies were pooled in the meta-analysis.

METHODS

Relevant studies were selected through an extensive search of PubMed, EMBASE, and the Web of Science databases. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random-effects model.

RESULTS

Six studies with were included in this systematic review and meta-analysis. There was no significant association between CX3CR1 T280M polymorphism and risk of AMD under all genetic models (TT vs

CC/CT: OR = 1.57, 95% CI = 0.87-2.84; CC vs TT/CT: OR = 0.75, 95% CI = 0.54-1.06; TT vs CC: OR = 0.58, 95% CI = 0.30-1.144; CT vs CC: OR = 1.25, 95% CI = 0.91-1.70). The CX3CR1 V249I polymorphism also did not significantly affect the AMD risk (AA vs

GG/AG: OR = 1.23, 95% CI = 0.98-1.55; AG/AA vs GG: OR = 0.56, 95% CI = 0.29-1.07; AA vs GG: OR = 1.43, 95% CI = 0.97-2.09; AG vs GG: OR = 1.07, 95% CI = 0.85-1.36).

CONCLUSIONS

This meta-analysis suggested that CX3CR1 T280M and V249I polymorphisms may not be associated with an increased risk of AMD based on current published data. Given the limited sample size, the finding on CX3CR1 polymorphisms needs further investigation.

摘要

目的

关于CX3CR1基因多态性与年龄相关性黄斑变性（AMD）之间关联的研究报告了相互矛盾的结果。因此，本荟萃分析旨在阐明CX3CR1 T280M和V249I多态性对AMD风险的影响。

设计

荟萃分析。

参与者

六项研究的结果被纳入荟萃分析。

方法

通过广泛检索PubMed、EMBASE和科学网数据库来选择相关研究。使用随机效应模型计算合并比值比（OR）和95%置信区间（CI）。

结果

六项研究被纳入本系统评价和荟萃分析。在所有遗传模型下，CX3CR1 T280M多态性与AMD风险之间均无显著关联（TT与CC/CT比较：OR = 1.57，95% CI = 0.87 - 2.84；CC与TT/CT比较：OR = 0.75，95% CI = 0.54 - 1.06；TT与CC比较：OR = 0.58，95% CI = 0.30 - 1.144；CT与CC比较：OR = 1.25，95% CI = 0.91 - 1.70）。CX3CR1 V249I多态性也未显著影响AMD风险（AA与GG/AG比较：OR = 1.23，95% CI = 0.98 - 1.55；AG/AA与GG比较：OR = 0.56，95% CI = 0.29 - 1.07；AA与GG比较：OR = 1.43，95% CI = 0.97 - 2.09；AG与GG比较：OR = 1.07，95% CI = 0.85 - 1.36）。