Fischer Martin, DeCaprio James A
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
EMBO J. 2015 Aug 4;34(15):1987-9. doi: 10.15252/embj.201592196. Epub 2015 Jun 18.
Strict temporal control of cell cycle gene expression is essential for all eukaryotes including animals and plants. DREAM complexes have been identified in worm, fly, and mammals, linking several distinct transcription factors to coordinate gene expression throughout the cell cycle. In this issue of The EMBO Journal, Kobayashi et al (2015) identify distinct activator and repressor complexes for genes expressed during the G2 and M phases in Arabidopsis that can be temporarily separated during proliferating and post‐mitotic stages of development. The complexes incorporate specific activator and repressor MYB and E2F transcription factors and indicate the possibility of the existence of multiple DREAM complexes in plants.
严格的细胞周期基因表达的时间控制对于包括动物和植物在内的所有真核生物至关重要。在蠕虫、果蝇和哺乳动物中已鉴定出DREAM复合物,它将几种不同的转录因子联系起来,以协调整个细胞周期中的基因表达。在本期《EMBO杂志》中,小林等人(2015年)鉴定出拟南芥中在G2和M期表达的基因的不同激活因子和抑制因子复合物,这些复合物在发育的增殖和有丝分裂后阶段可以暂时分离。这些复合物包含特定的激活因子和抑制因子MYB和E2F转录因子,表明植物中可能存在多种DREAM复合物。