Lafaro Kelly J, Cosgrove David, Geschwind Jean-Francois H, Kamel Ihab, Herman Joseph M, Pawlik Timothy M
Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Gastroenterol Res Pract. 2015;2015:860861. doi: 10.1155/2015/860861. Epub 2015 May 19.
Cholangiocarcinoma is a highly fatal primary cancer of the bile ducts which arises from malignant transformation of bile duct epithelium. While being an uncommon malignancy with an annual incidence in the United States of 5000 new cases, the incidence has been increasing over the past 30 years and comprises 3% of all gastrointestinal cancers. Cholangiocarcinoma can be classified into intrahepatic (ICC) and extrahepatic (including hilar and distal bile duct) according to its anatomic location within the biliary tree with respect to the liver. This paper reviews the management of ICC, focusing on the epidemiology, risk factors, diagnosis, and surgical and nonsurgical management.
胆管癌是一种起源于胆管上皮恶性转化的高度致命性胆管原发性癌症。虽然它是一种罕见的恶性肿瘤，在美国每年新发病例为5000例，但在过去30年中发病率一直在上升，占所有胃肠道癌症的3%。根据其在胆管树中相对于肝脏的解剖位置，胆管癌可分为肝内胆管癌（ICC）和肝外胆管癌（包括肝门部和远端胆管癌）。本文综述了肝内胆管癌的治疗，重点关注其流行病学、危险因素、诊断以及手术和非手术治疗。
