Khaledifar Arsalan, Mobasheri Mahmoud, Kheiri Soleiman, Zamani Zeinab
Assistant Professor, Echocardiography Fellowship, Department of Cardiology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Associate Professor, Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
ARYA Atheroscler. 2015 Jan;11(1):5-13.
Hypertension (HTN) is the most prevalent non-infectious disease worldwide and can lead to mortality. This trial aimed to compare the effect of N-acetylcysteine (NAC) and angiotensin-converting enzyme inhibitors (ACEIs) on controlling blood pressure in hypertensive patients.
This cross-sectional clinical trial was conducted in Hajar Hospital, Shahrekord, Iran, in 2009. A sample of 126 patients with HTN was selected and randomly divided into 2 groups (group A and group B). First, group A was treated with ACEI alone and group B with ACEI + NAC for 2 months. Blood pressure of all patients was evaluated each week. After a 2 week period of washout, the drugs were changed. In the second period of the trial, group A was treated with ACEI + NAC and group B with NAC alone and their blood pressure was evaluated in the same manner as the previous period. The data were analyzed using SPSS.
A significant reduction was observed in systolic and diastolic blood pressure of patients (P < 0.050). However, during both periods of the trial, the group receiving NAC + ACEI experienced a more significant reduction in blood pressure compared with the ACEI group (P < 0.050).
NAC accompanied with ACEI decreased the patients' systolic and diastolic blood pressure significantly; however, ACEI alone did not have any significant effects on blood pressure. Systolic blood pressure decreased 7 mmHg on average and fluctuated during the trial.
高血压是全球最常见的非传染性疾病，可导致死亡。本试验旨在比较N-乙酰半胱氨酸（NAC）和血管紧张素转换酶抑制剂（ACEI）对高血压患者血压控制的效果。
2009年在伊朗设拉子的哈贾尔医院进行了这项横断面临床试验。选取126例高血压患者样本，随机分为2组（A组和B组）。首先，A组单独使用ACEI治疗，B组使用ACEI + NAC治疗2个月。每周评估所有患者的血压。经过2周的洗脱期后，更换药物。在试验的第二阶段，A组使用ACEI + NAC治疗，B组单独使用NAC治疗，并以前期相同的方式评估其血压。使用SPSS分析数据。
患者的收缩压和舒张压均显著降低（P < 0.050）。然而，在试验的两个阶段中，与ACEI组相比，接受NAC + ACEI治疗的组血压降低更为显著（P < 0.050）。
NAC与ACEI联合使用可显著降低患者的收缩压和舒张压；然而，单独使用ACEI对血压没有任何显著影响。收缩压平均降低7 mmHg，且在试验期间有所波动。
