Hsu Chien-Ning, Tain You-Lin
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Antioxidants (Basel). 2021 Feb 5;10(2):247. doi: 10.3390/antiox10020247.
The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (HS), a crucial regulator of cardiovascular homeostasis, plays a pathogenetic role in CVD of developmental origins. Conversely, early HS-based interventions have proved beneficial in preventing adult-onset CVD in animal studies via reversing programming processes by so-called reprogramming. The focus of this review will first summarize the current knowledge on HS implicated in cardiovascular programming. This will be followed by supporting evidence for the links between HS signaling and underlying mechanisms of cardiovascular programming, such as oxidative stress, nitric oxide deficiency, dysregulated nutrient-sensing signals, activation of the renin-angiotensin system, and gut microbiota dysbiosis. It will also provide an overview from animal models regarding how HS-based reprogramming interventions, such as precursors of HS and HS donors, may prevent CVD of developmental origins. A better understanding of cardiovascular programming and recent advances in HS-based interventions might provide the answers to bring down the global burden of CVD.
心血管系统会受到多种早期生活应激因素的影响，从而在成年后引发心血管疾病（CVD）。这一概念现在被称为健康与疾病的发育起源（DOHaD）。新出现的证据表明，硫化氢（HS）作为心血管稳态的关键调节因子，在发育起源的心血管疾病中发挥着致病作用。相反，在动物研究中，基于早期硫化氢的干预措施已被证明通过所谓的重编程逆转编程过程，对预防成年期心血管疾病有益。本综述的重点将首先总结目前关于硫化氢参与心血管编程的知识。随后将提供支持硫化氢信号与心血管编程潜在机制之间联系的证据，这些机制包括氧化应激、一氧化氮缺乏、营养感知信号失调、肾素 - 血管紧张素系统激活以及肠道微生物群失调。它还将概述动物模型中基于硫化氢的重编程干预措施，如硫化氢前体和硫化氢供体，如何预防发育起源的心血管疾病。更好地理解心血管编程以及基于硫化氢的干预措施的最新进展，可能为降低全球心血管疾病负担提供答案。
