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加味九味羌活汤通过调控小鼠NF-κB信号通路减轻H1N1流感病毒诱导的严重肺损伤

The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF- κ B Pathway in Mice.

作者信息

Chen Lijuan, Yan Xin, Yan Qianlin, Fan Jiajun, Huang Hai, Shi Xunlong, Han Lei, Han Tianxiong, Zhu Haiyan

机构信息

Department of Chinese Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200092, China.

Institute of Chinese Medicine, Tongji University School of Medicine, Shanghai 200092, China.

出版信息

Evid Based Complement Alternat Med. 2015;2015:790739. doi: 10.1155/2015/790739. Epub 2015 May 18.

DOI:10.1155/2015/790739
PMID:26089947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4451524/
Abstract

A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice. The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-α on day 4 after infection. Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries. The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway. Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.

摘要

一种治疗高致病性流感病毒感染的新方法是抑制过度的先天性免疫反应。在中国，九味羌活汤已被用于治疗肺部疾病数百年。在本研究中，我们评估了改良九味羌活（MJWQH）汤对甲型流感（H1N1）病毒诱导的小鼠重症肺炎的抗炎活性。结果显示，MJWQH显著提高了H1N1感染小鼠的存活率，并在感染后第4天抑制了TNF-α、IL-1、IL-6、MCP-1、RANTES和IFN-α的产生。此外，口服MJWQH可有效抑制病毒复制并减轻肺损伤的严重程度。结果还表明，MJWQH可能通过调节NF-κB途径对H1N1病毒诱导的严重肺损伤具有潜在治疗作用。我们的研究表明，MJWQH可能是治疗病毒性肺炎的一种替代疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/ba2da077ec80/ECAM2015-790739.009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/ba2da077ec80/ECAM2015-790739.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/414697879fcf/ECAM2015-790739.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/79b3ec894aff/ECAM2015-790739.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/020c6482f012/ECAM2015-790739.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/bb2dec2ba103/ECAM2015-790739.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/cb02236bff8a/ECAM2015-790739.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/1e785d9189f3/ECAM2015-790739.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/e24c36ae27af/ECAM2015-790739.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/acec9435b6c4/ECAM2015-790739.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453b/4451524/ba2da077ec80/ECAM2015-790739.009.jpg

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