LaRowe Steven D, Kalivas Peter W
Substance Abuse Treatment Center, Mental Health Service Line, Ralph H. Johnson, VAMC, Charleston, SC. 29401 ; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston SC 29425.
Department of Neurosciences, Medical University of South Carolina, Charleston SC 29425.
Open Addict J. 2010;3:88-91. doi: 10.2174/1874941001003010088.
Previous work has found that N-acetylcysteine inhibits extinction responding in rats trained to self-administer heroin. The current study examined the ability of N-acetylcysteine to inhibit extinction responding in rats trained to self-administer cocaine. Rats were trained to self-administer cocaine (0.39mg/kg) for 10 to 12 days and were pretreated with either N-acetylcysteine (60mg/kg) or saline beginning on the first day of extinction training and on each extinction training day thereafter. Results indicated that chronically administered N-acetylcysteine reduced lever pressing during extinction sessions. In addition to demonstrating the impact N-acetylcysteine has on lever pressing during extinction, the present study underscores the importance of using responding during extinction as a dependent measure in the development of medications for addictive behaviors.
先前的研究发现，N-乙酰半胱氨酸可抑制经训练自行注射海洛因的大鼠的消退反应。本研究检测了N-乙酰半胱氨酸对经训练自行注射可卡因的大鼠消退反应的抑制能力。大鼠经训练自行注射可卡因（0.39毫克/千克）10至12天，并从消退训练的第一天及之后的每个消退训练日开始，分别用N-乙酰半胱氨酸（60毫克/千克）或生理盐水进行预处理。结果表明，长期给予N-乙酰半胱氨酸可减少消退训练期间的杠杆按压行为。除了证明N-乙酰半胱氨酸对消退训练期间杠杆按压行为的影响外，本研究还强调了在开发治疗成瘾行为的药物时，将消退反应作为一项依赖指标的重要性。
