Li Minglan, Reynolds Clare M, Segovia Stephanie A, Gray Clint, Vickers Mark H
Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
Biomed Res Int. 2015;2015:437107. doi: 10.1155/2015/437107. Epub 2015 May 18.
Nonalcoholic fatty liver disease (NAFLD) is fast becoming the most common liver disease globally and parallels rising obesity rates. The developmental origins of health and disease hypothesis have linked alterations in the early life environment to an increased risk of metabolic disorders in later life. Altered early life nutrition, in addition to increasing risk for the development of obesity, type 2 diabetes, and cardiovascular disease in offspring, is now associated with an increased risk for the development of NAFLD. This review summarizes emerging research on the developmental programming of NAFLD by both maternal obesity and undernutrition with a particular focus on the possible mechanisms underlying the development of hepatic dysfunction and potential strategies for intervention.
非酒精性脂肪性肝病（NAFLD）正迅速成为全球最常见的肝脏疾病，且与肥胖率上升同步。健康与疾病的发育起源假说将生命早期环境的改变与晚年代谢紊乱风险增加联系起来。生命早期营养改变，除了增加后代患肥胖症、2型糖尿病和心血管疾病的风险外，现在还与患NAFLD风险增加有关。本综述总结了关于母体肥胖和营养不良对NAFLD进行发育编程的新研究，特别关注肝功能障碍发展的潜在机制以及潜在的干预策略。
