[抗坏血酸给药对化学性肝癌发生过程中形成的3 - OAA抗原水平的影响]
[Effects of the administration of ascorbic acid on 3-OAA-antigen levels formed during chemical hepatocarcinogenesis].
作者信息
Korosteleva T A, Shvaĭdetskiĭ I I, Mishukov V I
出版信息
Vopr Onkol. 1989;35(12):1455-61.
PMID:2609541
Abstract
Variations in liver, blood and urine 3-oxyanthranilic acid-antigen (3-OAA-A) levels and those of ascorbic acid in liver of rats and mice receiving various hepatocarcinogens were examined. Treatment with ascorbic acid (three courses of 15 injections each) given prior to tumor development and during early carcinogenesis was followed by a significant decrease in 3-OAA-A concentration up to its complete elimination from the body and prevented hepatoma development.
摘要
检测了接受各种肝癌致癌物的大鼠和小鼠肝脏、血液及尿液中3-氧代邻氨基苯甲酸抗原（3-OAA-A）水平以及肝脏中抗坏血酸水平的变化。在肿瘤发生前及早期致癌过程中给予抗坏血酸治疗（分三个疗程，每个疗程注射15次），随后3-OAA-A浓度显著降低，直至其从体内完全消除，并预防了肝癌的发生。
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