[抗坏血酸对大鼠N-亚硝基二乙胺致癌作用的影响]
[Effect of ascorbic acid on the hepatocarcinogenic action of N-nitrosodiethylamine in rats].
作者信息
Birk R V, Kil'dema L A, Teras L E
出版信息
Eksp Onkol. 1988;10(6):66-8.
PMID:2854047
Abstract
It is shown that the ascorbic acid (AA) administration to Wistar male rats (50 mg per animal intraperitoneally 3 times a week) accelerates hepatocarcinogenesis induced by N-nitrosodiethylamine (2.5 mg/kg 6 times a week in drinking water). In this case the activity of glucose-6-phosphate dehydrogenase in liver increases, while that of glucose-6-phosphatase decreases.
摘要
结果表明，给雄性Wistar大鼠腹腔注射抗坏血酸（AA）（每只动物50毫克，每周3次）会加速由N-亚硝基二乙胺（每周6次，饮用水中浓度为2.5毫克/千克）诱导的肝癌发生。在这种情况下，肝脏中葡萄糖-6-磷酸脱氢酶的活性增加，而葡萄糖-6-磷酸酶的活性降低。
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