Miller D C, Wadsworth M J, Ross E M
Academic Department of Community Medicine, St. Mary's Hospital Medical School, London, UK.
Vaccine. 1989 Dec;7(6):487-9. doi: 10.1016/0264-410x(89)90268-5.
Dr. A. H. Griffith's article on this subject raises some important issues which require comment. We, like him, regret the controversy over the safety and efficacy of whole cell pertussis vaccines over the last 15 years. It does indeed represent a sorry saga whose principal victims are children, many of whom have not been vaccinated against this unpleasant and sometimes dangerous illness because of fears over safety of the vaccine. The National Childhood Encephalopathy Study (NCES), was set up in 1976 as an independent scientific enquiry into severe acute neurological illnesses associated with pertussis vaccine in an attempt to help resolve the matter. The report on the results concluded that these suggested, but did not prove, that the vaccine may very rarely cause the development of potentially damaging severe acute neurological illnesses in children who were previously apparently neurologically normal. Unfortunately the number of cases in the NCES was too small to allow any firm conclusions on whether or not the vaccine can cause permanent damage. The NCES has since been subject to intense scrutiny and criticism both by those who consider the vaccine can cause permanent neurological damage and by those, such as Dr Griffith, who consider it does not. Regrettably, the controversy continues.
A. H. 格里菲斯博士关于这个主题的文章提出了一些需要评论的重要问题。和他一样，我们对过去15年中关于全细胞百日咳疫苗安全性和有效性的争议感到遗憾。这确实是一段令人遗憾的经历，主要受害者是儿童，其中许多儿童由于担心疫苗的安全性而没有接种这种令人不适且有时危险的疾病的疫苗。国家儿童脑病研究（NCES）于1976年设立，作为一项独立的科学调查，旨在研究与百日咳疫苗相关的严重急性神经系统疾病，试图解决这个问题。关于结果的报告得出结论，这些结果表明，但并未证明，疫苗可能极罕见地会导致先前神经状况明显正常的儿童患上潜在损害性的严重急性神经系统疾病。不幸的是，NCES中的病例数量太少，无法就疫苗是否会造成永久性损伤得出任何确凿结论。此后，NCES受到了两方面的严格审查和批评，一方面是认为疫苗会导致永久性神经损伤的人，另一方面是像格里菲斯博士这样认为不会的人。遗憾的是，争议仍在继续。
