Luo Yong, Qiu Jianming
Department of Microbiology, Molecular Genetics & Immunology, University of Kansas Medical Center, Mail Stop 3029, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
Future Virol. 2015;10(2):155-167. doi: 10.2217/fvl.14.103.
Human parvovirus B19 (B19V) is a human pathogen that belongs to genus of the family, which is composed of a group of small DNA viruses with a linear single-stranded DNA genome. B19V mainly infects human erythroid progenitor cells and causes mild to severe hematological disorders in patients. However, recent clinical studies indicate that B19V also infects nonerythroid lineage cells, such as myocardial endothelial cells, and may be associated with other disease outcomes. Several cell culture systems, including permissive and semipermissive erythroid lineage cells, nonpermissive human embryonic kidney 293 cells and recently reported myocardial endothelial cells, have been used to study the mechanisms underlying B19V infection and B19V DNA replication. This review aims to summarize recent advances in B19V studies with a focus on the mechanisms of B19V tropism specific to different cell types and the cellular pathways involved in B19V DNA replication including cellular signaling transduction and cell cycle arrest.
人细小病毒B19（B19V）是一种人类病原体，属于该科的属，由一组具有线性单链DNA基因组的小DNA病毒组成。B19V主要感染人类红系祖细胞，并在患者中引起轻度至重度血液系统疾病。然而，最近的临床研究表明，B19V也感染非红系谱系细胞，如心肌内皮细胞，并可能与其他疾病结局相关。几种细胞培养系统，包括允许性和半允许性红系谱系细胞、非允许性人胚肾293细胞以及最近报道的心肌内皮细胞，已被用于研究B19V感染和B19V DNA复制的潜在机制。本综述旨在总结B19V研究的最新进展，重点关注B19V对不同细胞类型的嗜性机制以及参与B19V DNA复制的细胞途径，包括细胞信号转导和细胞周期停滞。
