Department of Toxicology and Risk Assessment, National Institute of Public Health - National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland.
Department of Radiation Hygiene and Radiobiology, National Institute of Public Health - National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland.
Sci Total Environ. 2015 Nov 1;532:548-55. doi: 10.1016/j.scitotenv.2015.06.050. Epub 2015 Jun 20.
The goal of this paper is to determine concentrations of seven selected perfluoroalkylated substances (PFASs): perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA) in the blood serum of men and women of reproductive age from the central region of Poland. The relation between sex of tested subjects and the levels of compounds in blood serum of humans will also be considered and analysed as an element of the risk assessment. The study was made on the blood serum samples collected from 253 women and 176 men of reproductive age between 20 and 44 years from Warsaw and surrounding areas. Higher concentrations of five (PFOS, PFOA, PFNA, PFDA, PFUnDA) from among seven selected PFASs were observed in men in comparison to women from the same populations. Only the concentrations of PFHxS and PFDoDA were slightly higher in women than in men. These differences were statistically significant in all cases, except for PFUnDA. The hypothesis that the concentrations of said compounds increase with age of the test subjects, regardless of gender has not been confirmed.
本文旨在测定波兰中部地区育龄男女血清中七种选定的全氟烷基物质（PFASs）的浓度：全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟己烷磺酸（PFHxS）、全氟壬酸（PFNA）、全氟癸酸（PFDA）、全氟十一烷酸（PFUnDA）和全氟十二烷酸（PFDoDA）。同时还将考虑并分析受试对象的性别与人体血清中化合物水平之间的关系，作为风险评估的一个要素。本研究采集了来自华沙及其周边地区 20 至 44 岁的 253 名女性和 176 名男性的血清样本。与同年龄段的女性相比，男性血清中七种选定的 PFASs 中有五种（PFOS、PFOA、PFNA、PFDA 和 PFUnDA）的浓度更高。只有 PFHxS 和 PFDoDA 在女性中的浓度略高于男性。除了 PFUnDA，所有情况下的这些差异均具有统计学意义。但受试对象的性别与年龄对上述化合物浓度的影响这一假设并未得到证实。
