在不同语言和发育能力水平上对女性自闭症表型的研究。
Female Autism Phenotypes Investigated at Different Levels of Language and Developmental Abilities.
作者信息
Howe Yamini J, O'Rourke Julia A, Yatchmink Yvette, Viscidi Emma W, Jones Richard N, Morrow Eric M
机构信息
Division of Developmental Behavioral Pediatrics, Department of Pediatrics, Hasbro Children's/Rhode Island Hospital, Brown University, Providence, RI, USA.
Lurie Center for Autism, Massachusetts General Hospital for Children, Lexington, MA, USA.
出版信息
J Autism Dev Disord. 2015 Nov;45(11):3537-49. doi: 10.1007/s10803-015-2501-y.
Abstract
This study investigated the differences in clinical symptoms between females and males with autism spectrum disorder (ASD) across three verbal ability groups (nonverbal, phrase and fluent speech), based on which Autism Diagnostic Observation Schedule module was administered to 5723 individuals in four research datasets. In the Simons Simplex Collection and Autism Treatment Network, females with ASD and phrase or fluent speech had lower cognitive, adaptive, and social abilities than males. In the Autism Genetics Resource Exchange and the Autism Consortium, females with phrase or fluent speech had similar or better adaptive and social abilities than males. Females who were nonverbal had similar cognitive, adaptive, and social abilities as males. Population-based longitudinal studies of verbally fluent females with ASD are needed.
摘要
本研究调查了自闭症谱系障碍（ASD）女性和男性在三个语言能力组（非语言、短语和流利言语）之间的临床症状差异，并据此对四个研究数据集中的5723名个体实施了自闭症诊断观察量表模块。在西蒙斯单纯型病例集和自闭症治疗网络中，患有ASD且能说出短语或流利言语的女性，其认知、适应和社交能力低于男性。在自闭症遗传学资源交流库和自闭症联盟中，能说出短语或流利言语的女性，其适应和社交能力与男性相似或更好。非言语女性的认知、适应和社交能力与男性相似。需要对患有ASD且言语流利的女性进行基于人群的纵向研究。
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