Yamashita M, Horigome H
Agressologie. 1989 Sep;30(8):489-91.
The effects of vagolysis with hyoscine butylbromide on left ventricular function were evaluated by echocardiography during halothane anaesthesia in children. Echocardiography showed deterioration of the following values after halothane induction; pre-ejection period, systolic time interval, left ventricular shortening fraction and ejection fraction. The first two values were improved by vagolysls with hyoscine butylbromide. However, relatively rate-independent indices, i.e. left ventricular shortening fraction and ejection fraction, still remained depressed even after vagolysis with hyoscine butylbromide. This implies that halothane-induced myocardial depression can only be partially antagonized by vagolysis.
在小儿氟烷麻醉期间，通过超声心动图评估了丁溴东莨菪碱迷走神经阻滞对左心室功能的影响。超声心动图显示，氟烷诱导后以下各项指标恶化：射血前期、收缩期时间间期、左心室缩短分数和射血分数。丁溴东莨菪碱迷走神经阻滞使前两项指标得到改善。然而，相对心率不相关的指标，即左心室缩短分数和射血分数，即使在丁溴东莨菪碱迷走神经阻滞后仍处于降低状态。这意味着氟烷诱导的心肌抑制只能被迷走神经阻滞部分拮抗。
