Wagner T, Botzler R, Ritter U
Z Gastroenterol. 1984 Jun;22(6):305-10.
The influence of the spasmolytic agent Hyoscine-N-butylbromide on the Cholecystokinin induced gallbladder contraction was investigated by ultrasonography in 25 volunteers. Even at a dosage of 0.15 mg/kg i.v. administered Hyoscine-N-butylbromide inhibited significantly the gallbladder emptying. In the investigated dosage range up to 0.6 mg/kg Hyoscine-N-butylbromide a strong response relationship was found. Since after the application of Hyoscine-N-butylbromide 30 min. before Cholecystokinin injection no loss of efficacy was observed, a considerably longer duration of the spasmolytic effect can be assumed. Also the oral form of the spasmolytic (dragees, mean dosage 0.6 mg/kg, application 30 min. before Cholecystokinin) showed a significant inhibition of gallbladder motility.
通过超声检查对25名志愿者研究了解痉剂丁溴东莨菪碱对胆囊收缩素诱导的胆囊收缩的影响。即使静脉注射剂量为0.15mg/kg的丁溴东莨菪碱也能显著抑制胆囊排空。在高达0.6mg/kg的研究剂量范围内，发现丁溴东莨菪碱有强烈的反应关系。由于在注射胆囊收缩素前30分钟应用丁溴东莨菪碱后未观察到疗效丧失，因此可以假定解痉作用持续时间长得多。解痉剂的口服剂型（糖衣丸，平均剂量0.6mg/kg，在注射胆囊收缩素前30分钟应用）也显示出对胆囊运动的显著抑制作用。
