Van Bever H P, Docx M, Stevens W J
Department of Paediatrics, University of Antwerp, Belgium.
Allergy. 1989 Nov;44(8):588-94. doi: 10.1111/j.1398-9995.1989.tb04205.x.
In this study the role of food additives, tyramine and acetylsalicylic acid, was investigated by double-blind placebo-controlled challenges (DBPCC) in 25 children with severe atopic dermatitis (AD). All children challenged with foods (n = 24), except one, showed one or more positive reactions to the DBPCC with foods. Positive reactions presented as different combinations of flares of skin symptoms, intestinal symptoms and respiratory symptoms. Seventeen children (70.8%) showed a positive challenge to egg, 12 to wheat (50%), eight to milk (33.3%) and eight to soya (33.3%). Six children underwent DBPCC with food additives, tyramine and acetylsalicylic acid. All were found to demonstrate positive skin and/or intestinal reactions to at least one of the food additives. Two children reacted to tartrazine, three to sodium benzoate, two to sodium glutamate, two to sodium metabisulfite, four to acetylsalicylic acid and one to tyramine. It is concluded that some foods, food additives, tyramine and acetylsalicylic acid, can cause positive DBPCC in children with severe AD.
在本研究中，通过双盲安慰剂对照激发试验（DBPCC）对25名重度特应性皮炎（AD）患儿研究了食品添加剂、酪胺和乙酰水杨酸的作用。除一名患儿外，所有接受食物激发试验的患儿（n = 24）对食物DBPCC均表现出一种或多种阳性反应。阳性反应表现为皮肤症状、肠道症状和呼吸道症状发作的不同组合。17名患儿（70.8%）对鸡蛋激发试验呈阳性，12名对小麦（50%）、8名对牛奶（33.3%）和8名对大豆（33.3%）呈阳性。6名患儿接受了食品添加剂、酪胺和乙酰水杨酸的DBPCC。发现所有患儿对至少一种食品添加剂均表现出阳性皮肤和/或肠道反应。2名患儿对酒石黄有反应，3名对苯甲酸钠、2名对谷氨酸钠、2名对偏亚硫酸氢钠、4名对乙酰水杨酸、1名对酪胺有反应。得出的结论是，某些食物、食品添加剂、酪胺和乙酰水杨酸可在重度AD患儿中引起阳性DBPCC。
