Lo Cicero Alessandra, Delevoye Cédric, Gilles-Marsens Floriane, Loew Damarys, Dingli Florent, Guéré Christelle, André Nathalie, Vié Katell, van Niel Guillaume, Raposo Graça
1] Institut Curie, PSL Research University, UMR144, CNRS, F-75248 Paris, France [2] Structure and Membrane Compartments, Centre National de la Recherche Scientifique, UMR144, Paris F-75248, France [3] Cell and Tissue Imaging Facility, Infrastructures en Biologie Santé et Agronomie (IBiSA), Paris F-75248, France.
1] Institut Curie, PSL Research University, UMR144, CNRS, F-75248 Paris, France [2] Structure and Membrane Compartments, Centre National de la Recherche Scientifique, UMR144, Paris F-75248, France.
Nat Commun. 2015 Jun 24;6:7506. doi: 10.1038/ncomms8506.
Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states.
细胞分泌细胞外囊泡（EVs）、外泌体和微囊泡，它们可转运蛋白质、脂质和RNA以调节受体细胞功能。皮肤色素沉着依赖于表皮中角质形成细胞和黑素细胞之间的紧密对话。在此，我们报告角质形成细胞分泌的外泌体通过增加黑素小体蛋白的表达和活性来增强黑色素合成。此外，我们表明角质形成细胞来源的外泌体的功能依赖于皮肤光类型，并受紫外线B调节。总之，本研究揭示了外泌体在人类色素沉着中的重要生理功能，并为我们理解在健康和疾病状态下色素沉着如何通过细胞间通讯进行调节开辟了新途径。
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