Sun Zixuan, Li Jiali, Wu Zhijing, Zhang Jiaxin, Wang Tangrong, Zheng Yuzhou, Xu XueZhong, Ding Wei, Qian Hui, Tan Yulin
Department of General Surgery, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Jiangsu, Changzhou 213017, China.
Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, No. 301 Xuefu Road, Jiangsu, Zhenjiang 212013, China.
Burns Trauma. 2025 May 17;13:tkaf033. doi: 10.1093/burnst/tkaf033. eCollection 2025.
The persistent desire for beauty has fueled the rapid development of medical aesthetics. Multiple approaches, including cosmetics, drugs, and cell therapies, have been developed to improve skin conditions. However, none of these methods achieves the intended outcomes and may produce adverse repercussions. Consequently, it is crucial to develop effective and safe therapies to promote skin repair and regeneration. Extracellular vesicles (EVs) are cell-derived, lipid bilayer-encapsulated nanoparticles containing multiple active components. There is now strong evidence that EV therapies can improve skin barrier function, reduce scarring, inhibit aging and pigmentation, and suppress hair loss, highlighting the potential for cosmeceutical development based on EVs. This review summarizes the latest applications of natural EVs, preconditioned and engineered EVs, and EV mimetics in medical aesthetics. Additionally, the article discusses advanced delivery strategies for EVs and the commercial prospects of EVs and provides insights into present security concerns, regulations, and the field's future directions.
对美的持续追求推动了医学美学的快速发展。人们已经开发出多种方法，包括化妆品、药物和细胞疗法，来改善皮肤状况。然而，这些方法都没有达到预期效果，而且可能产生不良反应。因此，开发有效且安全的疗法以促进皮肤修复和再生至关重要。细胞外囊泡（EVs）是细胞来源的、脂质双层包裹的纳米颗粒，含有多种活性成分。现在有充分的证据表明，EV疗法可以改善皮肤屏障功能、减少疤痕形成、抑制衰老和色素沉着以及抑制脱发，这凸显了基于EVs进行化妆品开发的潜力。本综述总结了天然EVs、预处理和工程化EVs以及EV模拟物在医学美学中的最新应用。此外，本文还讨论了EVs的先进递送策略以及EVs的商业前景，并对当前的安全问题、法规以及该领域的未来方向提供了见解。
