Majigsuren Mungunkhuyag, Abe Takashi, Kageji Teruyoshi, Matsuzaki Kenji, Takeuchi Mayumi, Iwamoto Seiji, Otomi Yoichi, Uyama Naoto, Nagahiro Shinji, Harada Masafumi
Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School.
Magn Reson Med Sci. 2016;15(1):34-40. doi: 10.2463/mrms.2014-0129. Epub 2015 Jun 23.
T1-Cube (GE HealthCare) is a relatively new 3-dimensional (3D) fast spin-echo (FSE)-based magnetic resonance (MR) imaging sequence that uses a variable flip angle to acquire gap-free volume scans. We compared the gadolinium enhancement characteristics of a heterogeneous population of brain tumors imaged by T1-Cube and then 3D fast spoiled gradient recall acquisition in steady state (3D FSPGR) 3-tesla MR imaging to identify the superior modality for specific diagnostic purposes.
We examined 61 lesions from 32 patients using the 2 sequences after administration of gadopentetic acid (Gd-DTPA; 0.1 mmol/kg). Two neuroradiologists independently measured each lesion twice using a region-of-interest (ROI) method. We measured the contrast-to-noise ratio (CNR), the difference in signal intensity (SI) between the tumor and normal white matter relative to the standard deviation (SD) of the SI within the lesion, for both post-contrast 3D FSPGR and post-contrast T1-Cube images of the same tumor and compared modality-specific CNRs for all tumors and in subgroups defined by tumor size, enhancement ratio, and histopathology.
The mean CNR was significantly higher on T1-Cube images than 3D FSPGR images for the total tumor population (1.85 ± 0.97 versus 1.12 ± 1.05, P < 0.01) and the histologic types, i.e., metastasis (P < 0.01) and lymphoma (P < 0.05). The difference in CNR was even larger for smaller tumors in the metastatic group (4.95 to 23.5 mm(2)) (P < 0.01). In contrast, mean CNRs did not differ between modalities for high grade glioma and meningioma.
Gadolinium enhancement of brain tumors was generally higher when imaged by T1-Cube than 3D FSPGR, and T1-Cube with Gd enhancement may be superior to 3D FSPGR for detecting smaller metastatic tumors.
T1-Cube（通用电气医疗集团）是一种相对较新的基于三维（3D）快速自旋回波（FSE）的磁共振（MR）成像序列，它使用可变翻转角来获取无间隙容积扫描。我们比较了通过T1-Cube成像的异质性脑肿瘤群体的钆增强特征，然后在3特斯拉MR成像中进行三维快速扰相梯度回波稳态采集（3D FSPGR），以确定用于特定诊断目的的更优成像方式。
在给予钆喷酸葡胺（Gd-DTPA；0.1 mmol/kg）后，我们使用这两种序列检查了32例患者的61个病变。两位神经放射科医生使用感兴趣区（ROI）方法对每个病变独立测量两次。我们测量了同一肿瘤的对比增强三维快速扰相梯度回波（3D FSPGR）和对比增强T1-Cube图像的对比噪声比（CNR），即肿瘤与正常白质之间的信号强度（SI）差异相对于病变内SI的标准差（SD），并比较了所有肿瘤以及按肿瘤大小、增强率和组织病理学定义的亚组中特定成像方式的CNR。
对于全部肿瘤群体（1.85±0.97对1.12±1.05，P<0.01）以及组织学类型，即转移瘤（P<0.01）和淋巴瘤（P<0.05），T1-Cube图像上的平均CNR显著高于3D FSPGR图像。在转移瘤组中，较小肿瘤（4.95至23.5 mm²）的CNR差异甚至更大（P<0.01）。相比之下，高级别胶质瘤和脑膜瘤在不同成像方式之间的平均CNR没有差异。
脑肿瘤的钆增强在通过T1-Cube成像时通常高于3D FSPGR，并且钆增强T1-Cube在检测较小转移瘤方面可能优于3D FSPGR。
