Hasegawa Hirokazu, Ashikaga Ryuichiro, Okajima Kaoru, Wakayama Tetsuya, Miyoshi Mitsuharu, Nishimura Yasumasa, Murakami Takamichi
Department of Radiology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1, Otodacho, Ikoma, Nara, 630-0293, Japan.
GE Healthcare Japan, MR Applications and Workflow, Asia Pacific, 4-7-127, Asahigaoka, Hino, Tokyo, 191-8503, Japan.
Jpn J Radiol. 2017 Aug;35(8):463-471. doi: 10.1007/s11604-017-0654-7. Epub 2017 May 24.
This study aimed to compare the detectability of neoplastic lesion enhancement after gadolinium-based contrast media injection in three-dimensional T1-weighted black blood Cube (3D-T1W BB Cube) and three-dimensional T1-weighted fast spoiled gradient-echo (3D-T1W fast SPGR) images obtained with 1.5-T magnetic resonance imaging (MRI).
Phantom and clinical studies were performed to compare the lesion detectability and contrast ratio (CR) between 3D-T1W BB Cube and 3D-T1W fast SPGR pulse sequences.
In the phantom study, the CRs for 3D-T1W BB Cube and 3D-T1W fast SPGR were equivalent at low gadolinium concentrations (0.125-1.25 mmol/l). In the clinical study, the detectability in the two modalities was similar for enhanced lesions ≥5 mm, but was significantly better in 3D-T1W BB Cube for lesions <5 mm (p = 0.011). Similarly, the CRs in both modalities were similar for lesions ≥5 mm (0.66 ± 0.36 vs. 0.56 ± 0.30, p = 0.153), but significantly lower in 3D-T1W BB Cube images for lesions <5 mm (0.29 ± 0.19 vs. 0.39 ± 0.21, p = 0.006).
Contrast 3D-T1W BB Cube imaging appears more sensitive than 3D-T1W fast SPGR imaging for detecting neoplastic lesion enhancement in the clinical setting using a 1.5-T MRI scanner, particularly for lesions <5 mm in diameter.
本研究旨在比较在1.5-T磁共振成像（MRI）获得的三维T1加权黑血立方（3D-T1W BB Cube）和三维T1加权快速扰相梯度回波（3D-T1W fast SPGR）图像中，注射钆基造影剂后肿瘤性病变强化的可检测性。
进行了体模和临床研究，以比较3D-T1W BB Cube和3D-T1W fast SPGR脉冲序列之间的病变可检测性和对比率（CR）。
在体模研究中，低钆浓度（0.125 - 1.25 mmol/l）时，3D-T1W BB Cube和3D-T1W fast SPGR的CRs相当。在临床研究中，对于≥5 mm的强化病变，两种模式下的可检测性相似，但对于<5 mm的病变，3D-T1W BB Cube的可检测性显著更好（p = 0.011）。同样，对于≥5 mm的病变，两种模式下的CRs相似（0.66 ± 0.36 vs. 0.56 ± 0.30，p = 0.153），但对于<5 mm的病变，3D-T1W BB Cube图像中的CRs显著更低（0.29 ± 0.19 vs. 0.39 ± 0.21，p = 0.006）。
在使用1.5-T MRI扫描仪的临床环境中，对比增强3D-T1W BB Cube成像在检测肿瘤性病变强化方面似乎比3D-T1W fast SPGR成像更敏感，特别是对于直径<5 mm的病变。
