Hove Michael J, Zeffiro Thomas A, Biederman Joseph, Li Zhi, Schmahmann Jeremy, Valera Eve M
Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA.
Neurometrika, Potomac, MD 20854, USA.
Neuroimage Clin. 2015 May 21;8:422-8. doi: 10.1016/j.nicl.2015.05.005. eCollection 2015.
Motor abnormalities, including impaired balance and increased postural sway, are commonly reported in children with ADHD, but have yet to be investigated in adults with ADHD. Furthermore, although these abnormalities are thought to stem from cerebellar deficits, evidence for an association between the cerebellum and these motor deficits has yet to be provided for either adults or children with ADHD.
In this study, we measured postural sway in adults with ADHD and controls, examining the relationship between sway and regional cerebellar gray matter volume. Thirty-two ADHD and 28 control participants completed various standing-posture tasks on a Wii balance board.
Postural sway was significantly higher for the ADHD group compared to the healthy controls. Higher sway was positively associated with regional gray matter volume in the right posterior cerebellum (lobule VIII/IX).
These findings show that sway abnormalities commonly reported in children with ADHD are also present in adults, and for the first time show a relationship between postural control atypicalities and the cerebellum in this group. Our findings extend the literature on motor abnormalities in ADHD and contribute to our knowledge of their neural substrate.
运动异常，包括平衡受损和姿势摆动增加，在多动症儿童中普遍存在，但尚未在多动症成人中进行研究。此外，尽管这些异常被认为源于小脑缺陷，但针对多动症成人或儿童，小脑与这些运动缺陷之间关联的证据尚未得到证实。
在本研究中，我们测量了多动症成人和对照组的姿势摆动，研究摆动与小脑局部灰质体积之间的关系。32名多动症参与者和28名对照参与者在Wii平衡板上完成了各种站立姿势任务。
与健康对照组相比，多动症组的姿势摆动明显更高。较高的摆动与右后小脑（小叶VIII/IX）的局部灰质体积呈正相关。
这些发现表明，多动症儿童中常见的摆动异常在成人中也存在，并且首次表明该群体中姿势控制异常与小脑之间存在关联。我们的研究结果扩展了关于多动症运动异常的文献，并有助于我们了解其神经基础。
