Department of Pediatrics-Critical Care, University of Colorado Denver , Denver, CO , USA ; Cardiovascular Pulmonary Research, University of Colorado Denver , Denver, CO , USA ; Department of Bioengineering, University of Colorado Denver , Denver, CO , USA ; Linda Crnic Institute for Down Syndrome, University of Colorado Denver , Denver, CO , USA.
Front Pediatr. 2015 Jun 9;3:45. doi: 10.3389/fped.2015.00045. eCollection 2015.
Pediatric lung diseases remain a costly worldwide health burden. For many children with end-stage lung disease, lung transplantation remains the only therapeutic option. Due to the limited number of lungs available for transplantation, alternatives to lung transplant are desperately needed. Recently, major improvements in tissue engineering have resulted in newer technology and methodology to develop viable bioengineered lungs. These include critical advances in lung cell biology, stem cell biology, lung extracellular matrix, microfabrication techniques, and orthotopic transplantation of bioartificial lungs. The goal of this short review is to engage the reader's interest with regard to these emerging concepts and to stimulate their interest to learn more. We review the existing state of the art of lung tissue engineering, and point to emerging paradigms and platforms in the field. Finally, we summarize the challenges and unmet needs that remain to be overcome.
儿科肺部疾病仍然是全球范围内昂贵的健康负担。对于许多患有终末期肺部疾病的儿童来说，肺移植仍然是唯一的治疗选择。由于可用于移植的肺部数量有限，因此迫切需要替代肺移植的方法。最近，组织工程学的重大进展带来了更新的技术和方法，以开发可行的生物工程肺。这些包括在肺细胞生物学、干细胞生物学、肺细胞外基质、微制造技术和生物人工肺的原位移植方面的重要进展。这篇短文的目的是引起读者对这些新兴概念的兴趣，并激发他们进一步了解的兴趣。我们回顾了肺组织工程学的现有最新技术，并指出了该领域正在出现的范例和平台。最后，我们总结了仍然需要克服的挑战和未满足的需求。
