Sanches Bruno Fernandes, Morgado Joana, Carvalho Nuno, Anjos Rui
Department of Pediatrics, Hospital Garcia de Orta, Almada, Portugal.
Department of Pediatrics, Hospital Espírito Santo, Évora, Portugal.
BMJ Case Rep. 2015 Jun 24;2015:bcr2014207033. doi: 10.1136/bcr-2014-207033.
Infectious complications represent an important cause of morbidity and death in patients with transplant. Parasitic infections are less frequent than viral and bacterial agents, and are often overlooked. We describe the case of a 13-year-old adolescent, born in São Tomé Island, who was under immunosuppressive therapy after a cardiac transplant. The patient had an intermittent course of diarrhoea, abdominal pain and vomiting. She was admitted dehydrated, and Strongyloides stercoralis, Schistosoma intercalatum and Cystoisospora belli were isolated in her stools. The patient was treated with ivermectin, albendazole, praziquantel and ciprofloxacin with clinical and microbiological resolution. Her immunosuppressive therapy was reduced during hospitalisation. We believe that the parasitic infection was a result of a recrudescence of dormant infections acquired in her homeland. To the best of our knowledge, there are no reports of cystoisosporiasis or schistosomiasis in heart transplant recipients.
感染性并发症是移植患者发病和死亡的重要原因。寄生虫感染比病毒和细菌感染少见,且常被忽视。我们描述了一名13岁青少年的病例,该患者出生于圣多美岛,心脏移植后接受免疫抑制治疗。患者有间歇性腹泻、腹痛和呕吐症状。她因脱水入院,粪便中分离出粪类圆线虫、间插血吸虫和贝氏等孢球虫。患者接受了伊维菌素、阿苯达唑、吡喹酮和环丙沙星治疗,临床症状和微生物学检查结果均显示好转。住院期间她的免疫抑制治疗有所减少。我们认为寄生虫感染是其在祖国获得的潜伏感染复发所致。据我们所知,尚无心脏移植受者发生等孢球虫病或血吸虫病的报道。