筛查、预防和治疗粪类圆线虫引起的超感染综合征和播散性感染。
Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis.
机构信息
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.
出版信息
Curr Opin Infect Dis. 2012 Aug;25(4):458-63. doi: 10.1097/QCO.0b013e3283551dbd.
Abstract
PURPOSE OF REVIEW
This review discusses the latest approaches to the diagnosis and treatment of patients with strongyloidiasis, with an emphasis on infection in the immunocompromised host and the risk for disseminated strongyloidiasis.
RECENT FINDINGS
The differences in acute, chronic, accelerated autoinfection, and disseminated disease in Strongyloides stercoralis infection are explored with particular emphasis on early diagnosis, treatment, and prevention. The goals of treatment are investigated for the different infection states. Predisposing risks for dissemination are delineated, and the roles played for newer diagnostics in the identification of at-risk individuals are detailed.
SUMMARY
The use of newer diagnostic tests and broader screening of immunocompromised patients from Strongyloides-endemic areas is of paramount importance, particularly if prevention of life-threatening dissemination is the goal.
摘要
目的综述
本文讨论了当前针对粪类圆线虫病患者的诊断和治疗方法，重点关注免疫功能低下宿主的感染和播散性粪类圆线虫病的风险。
最近的发现
本文探讨了粪类圆线虫感染中急性、慢性、加速性自身感染和播散性疾病的差异，特别强调了早期诊断、治疗和预防。研究了不同感染状态的治疗目标。阐述了播散的诱发风险，并详细介绍了新诊断方法在识别高危人群中的作用。
总结
对来自粪类圆线虫流行地区的免疫功能低下患者进行新的诊断检测和更广泛的筛查至关重要，特别是如果目标是预防危及生命的播散。
相似文献
1
Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis.筛查、预防和治疗粪类圆线虫引起的超感染综合征和播散性感染。
Curr Opin Infect Dis. 2012 Aug;25(4):458-63. doi: 10.1097/QCO.0b013e3283551dbd.
2
Manifestations, diagnosis, and treatment of Strongyloides stercoralis infection.粪类圆线虫感染的表现、诊断及治疗
Ann Pharmacother. 2007 Dec;41(12):1992-2001. doi: 10.1345/aph.1K302. Epub 2007 Oct 16.
3
Strongyloides stercoralis infection in patients with systemic lupus erythematosus: diagnosis and prevention of severe strongyloidiasis.系统性红斑狼疮患者的粪类圆线虫感染：重度类圆线虫病的诊断与预防
Int J Rheum Dis. 2016 Jul;19(7):700-5. doi: 10.1111/1756-185X.12644. Epub 2015 Aug 10.
4
[Disseminated strongyloidiasis].播散性类圆线虫病
Presse Med. 2001 Apr 28;30(16):813-8.
5
[Strongyloides stercoralis hyperinfection syndrome in a patient with Behçet's Disease].[一名白塞病患者的粪类圆线虫超感染综合征]
Turkiye Parazitol Derg. 2013;37(2):139-42. doi: 10.5152/tpd.2013.30.
6
Management of Strongyloides stercoralis: a puzzling parasite.粪类圆线虫感染的管理：一种令人费解的寄生虫。
Int Health. 2014 Dec;6(4):273-81. doi: 10.1093/inthealth/ihu058. Epub 2014 Aug 30.
7
Intestinal strongyloidiasis: a diagnosis frequently missed in the tropics.肠道类圆线虫病：一种在热带地区经常被漏诊的疾病。
Trans R Soc Trop Med Hyg. 2009 Mar;103(3):242-6. doi: 10.1016/j.trstmh.2008.08.009. Epub 2008 Sep 20.
8
Strongyloides hyperinfection: a treatment dilemma.类圆线虫重度感染：一个治疗难题。
Am J Med Sci. 2008 Oct;336(4):358-61. doi: 10.1097/MAJ.0b013e31815cff89.
9
Diagnosis of Strongyloides stercoralis infection.粪类圆线虫感染的诊断。
Clin Infect Dis. 2001 Oct 1;33(7):1040-7. doi: 10.1086/322707. Epub 2001 Sep 5.
10
Fatal outcome in a patient under immunosuppressant therapy infected with human T-lymphotropic virus type 1 (HTLV-1), cytomegalovirus (CMV) and Strongyloides stercoralis: a case report.免疫抑制剂治疗患者感染人嗜 T 淋巴细胞病毒 1 型（HTLV-1）、巨细胞病毒（CMV）和粪类圆线虫：1 例报告。
BMC Infect Dis. 2020 Jul 2;20(1):470. doi: 10.1186/s12879-020-05195-0.
引用本文的文献
1
A 53-year-old woman with necrotising myopathy presenting with cough and respiratory distress: a diagnostic conundrum.一名53岁患有坏死性肌病的女性，出现咳嗽和呼吸窘迫：一个诊断难题。
Breathe (Sheff). 2025 Aug 19;21(3):250009. doi: 10.1183/20734735.0009-2025. eCollection 2025 Jul.
2
Strongyloides Infection Presenting as Meningitis Post-Transplant.移植后以脑膜炎形式出现的类圆线虫感染
Trop Med Infect Dis. 2025 May 20;10(5):143. doi: 10.3390/tropicalmed10050143.
3
Gas, Larvae, Coagulopathy, and a Rare Culprit: Emphysematous Cystitis and Enterococcus raffinosus Ventriculitis Triggered by Strongyloides Hyperinfection Syndrome.气体、幼虫、凝血障碍及一个罕见病因：类圆线虫超感染综合征引发的气肿性膀胱炎和棉子糖肠球菌脑室炎
Cureus. 2025 Apr 17;17(4):e82417. doi: 10.7759/cureus.82417. eCollection 2025 Apr.
4
The Unwelcome Guest: Hyperinfection in a Patient With Steroid-Dependent Asthma-COPD Overlap Syndrome (ACOS)-A Case Report and Review of Literature.不受欢迎的客人：类固醇依赖型哮喘-慢性阻塞性肺疾病重叠综合征（ACOS）患者的播散性感染——病例报告及文献综述
Case Rep Pulmonol. 2025 Mar 19;2025:3204304. doi: 10.1155/crpu/3204304. eCollection 2025.
5
Genetic Diversity of with Attention to Clinical Features in Patients Originated from Three Endemic Provinces in the North and South of Iran.关注伊朗南北三个地方病省份患者临床特征的[具体研究对象]的遗传多样性 。（原文中“with Attention to Clinical Features in Patients Originated from Three Endemic Provinces in the North and South of Iran”部分前面应该有具体所研究的主体，这里按要求翻译，但句子不太完整）
Iran J Parasitol. 2024 Oct-Dec;19(4):465-474. doi: 10.18502/ijpa.v19i4.17167.
6
Seroconversion and seroreversion rates of anti-Strongyloides IgG in rural areas of the Amazon: a population-based panel study.亚马逊农村地区抗粪类圆线虫IgG的血清转化和血清逆转率：一项基于人群的队列研究。
Rev Inst Med Trop Sao Paulo. 2024 Dec 6;66:e72. doi: 10.1590/S1678-9946202466072. eCollection 2024.
7
Strongyloides Hyperinfection Syndrome Following Immunosuppressant Therapy for COVID-19: A Case Report With Literature Review.新冠病毒病免疫抑制治疗后发生的类圆线虫重度感染综合征：一例报告并文献复习
Clin Case Rep. 2024 Dec 6;12(12):e9689. doi: 10.1002/ccr3.9689. eCollection 2024 Dec.
8
Coinfection of cytomegalovirus and strongyloidiasis presenting as massive gastrointestinal bleeding in an immunocompromised host: a case report.巨细胞病毒与粪类圆线虫双重感染在免疫功能低下宿主中表现为大量胃肠道出血：一例报告
Front Med (Lausanne). 2024 Nov 20;11:1438689. doi: 10.3389/fmed.2024.1438689. eCollection 2024.
9
Pneumonia in Transplant Recipients: A Comprehensive Review of Diagnosis and Management.移植受者的肺炎：诊断与管理的全面综述
Cureus. 2024 Nov 14;16(11):e73669. doi: 10.7759/cureus.73669. eCollection 2024 Nov.
10
Concomitant Serological and Molecular Methods for Screening in an Endemic Area of Spain.西班牙一个地方性流行区的血清学与分子联合筛查方法
Trop Med Infect Dis. 2024 Aug 25;9(9):194. doi: 10.3390/tropicalmed9090194.
本文引用的文献
1
Prevalence of Strongyloides stercoralis infection among HIV-positive immigrants attending two Italian hospitals, from 2000 to 2009.2000年至2009年期间，两家意大利医院收治的HIV阳性移民中粪类圆线虫感染的患病率。
Ann Trop Med Parasitol. 2011 Dec;105(8):617-23. doi: 10.1179/2047773211Y.0000000006.
2
Strongyloidiasis: prevalence, risk factors, clinical and laboratory features among diarrhea patients in Ibadan Nigeria.类圆线虫病：尼日利亚伊巴丹腹泻患者中的患病率、危险因素、临床及实验室特征
Afr J Med Med Sci. 2010 Dec;39(4):285-92.
3
Strongyloidiasis presenting as duodenal obstruction in a patient infected with human T-cell lymphotropic virus type 1.在一名感染1型人类嗜T细胞病毒的患者中，类圆线虫病表现为十二指肠梗阻。
Gastrointest Endosc. 2011 Aug;74(2):439-41. doi: 10.1016/j.gie.2010.11.035. Epub 2011 Jun 25.
4
Strongyloides stercoralis in common vegetables and herbs in Kota Bharu, Kelantan, Malaysia.马来西亚吉兰丹哥打巴鲁常见蔬菜和草药中的粪类圆线虫
Trop Biomed. 2011 Apr;28(1):188-93.
5
Efficacy and safety of single and double doses of ivermectin versus 7-day high dose albendazole for chronic strongyloidiasis.伊维菌素单剂量和双剂量与 7 天高剂量阿苯达唑治疗慢性旋毛虫病的疗效和安全性。
PLoS Negl Trop Dis. 2011 May 10;5(5):e1044. doi: 10.1371/journal.pntd.0001044.
6
Strongyloidiasis in man 75 years after initial exposure.初次感染75年后的人类类圆线虫病。
Emerg Infect Dis. 2011 May;17(5):931-2. doi: 10.3201/eid1705.100490.
7
Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma.播散性粪类圆线虫感染与人类嗜 T 淋巴细胞病毒 1 型相关的成人 T 细胞白血病/淋巴瘤。
Acta Haematol. 2011;126(2):63-7. doi: 10.1159/000324799. Epub 2011 Apr 7.
8
Travel-related schistosomiasis, strongyloidiasis, filariasis, and toxocariasis: the risk of infection and the diagnostic relevance of blood eosinophilia.旅行相关的血吸虫病、类圆线虫病、丝虫病和弓蛔虫病：感染风险和血液嗜酸性粒细胞增多的诊断相关性。
BMC Infect Dis. 2011 Apr 5;11:84. doi: 10.1186/1471-2334-11-84.
9
Update on strongyloidiasis in the immunocompromised host.免疫功能低下宿主中类圆线虫病的研究进展。
Curr Infect Dis Rep. 2011 Feb;13(1):35-46. doi: 10.1007/s11908-010-0150-z.
10
High throughput multiplex PCR and probe-based detection with Luminex beads for seven intestinal parasites.高通量多重 PCR 和基于 Luminex 珠子的探针检测七种肠道寄生虫。
Am J Trop Med Hyg. 2011 Feb;84(2):332-7. doi: 10.4269/ajtmh.2011.10-0461.
Zotero 插件