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The therapeutic potential of mesenchymal stem cells in Alzheimer's disease: converging mechanisms.

作者信息

Turgeman Gadi

机构信息

Department of Pre-Medical Studies & Department of Molecular Biology, Ariel University, Ariel, Israel.

出版信息

Neural Regen Res. 2015 May;10(5):698-9. doi: 10.4103/1673-5374.156953.

DOI:10.4103/1673-5374.156953
PMID:26109936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4468753/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/095b/4468753/679c282faa74/NRR-10-698-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/095b/4468753/e4735f664dda/NRR-10-698-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/095b/4468753/679c282faa74/NRR-10-698-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/095b/4468753/e4735f664dda/NRR-10-698-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/095b/4468753/679c282faa74/NRR-10-698-g002.jpg

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本文引用的文献

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Mesenchymal stem cells can prevent alterations in behavior and neurogenesis induced by Aß25-35 administration.间充质干细胞可以预防由给予Aβ25-35所诱导的行为改变和神经发生。
J Mol Neurosci. 2015 Apr;55(4):1006-13. doi: 10.1007/s12031-014-0457-6. Epub 2014 Nov 12.
2
Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice.脂肪间充质干细胞移植可促进阿尔茨海默病小鼠大脑中的成年神经发生。
Neural Regen Res. 2014 Apr 15;9(8):798-805. doi: 10.4103/1673-5374.131596.
3
Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease.
间充质干细胞移植改善了小脑共济失调小鼠模型中阿糖胞苷诱导的运动功能障碍。
J Clin Med. 2023 Feb 22;12(5):1756. doi: 10.3390/jcm12051756.
4
Mesenchymal stromal cell treatment attenuates repetitive mild traumatic brain injury-induced persistent cognitive deficits via suppressing ferroptosis.间充质基质细胞治疗通过抑制铁死亡减轻重复性轻度创伤性脑损伤引起的持续性认知缺陷。
J Neuroinflammation. 2022 Jul 14;19(1):185. doi: 10.1186/s12974-022-02550-7.
5
Extracellular Vesicles of Mesenchymal Stromal Cells Can be Taken Up by Microglial Cells and Partially Prevent the Stimulation Induced by β-amyloid.间质基质细胞的细胞外囊泡可被小神经胶质细胞摄取,并部分阻止β-淀粉样蛋白诱导的刺激。
Stem Cell Rev Rep. 2022 Mar;18(3):1113-1126. doi: 10.1007/s12015-021-10261-4. Epub 2022 Jan 26.
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Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation.人间充质干细胞在伴有神经炎症的小鼠小脑共济失调模型中的治疗作用
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Transplantation of mesenchymal stem cells causes long-term alleviation of schizophrenia-like behaviour coupled with increased neurogenesis.间充质干细胞移植可长期缓解精神分裂症样行为,并增加神经发生。
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Mol Neurobiol. 2017 Nov;54(9):7401-7459. doi: 10.1007/s12035-016-0214-7. Epub 2016 Nov 5.
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Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease.人脐带干细胞异种移植改善阿尔茨海默病小鼠模型的认知衰退并减轻淀粉样蛋白负担。
Curr Alzheimer Res. 2017;14(1):104-111. doi: 10.2174/1567205013666161004151416.
靶向神经发生可改善阿尔茨海默病小鼠模型中的危险评估。
Behav Brain Res. 2014 Mar 15;261:193-201. doi: 10.1016/j.bbr.2013.12.028. Epub 2013 Dec 31.
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Neuropathological approaches to cerebral aging and neuroplasticity.脑衰老与神经可塑性的神经病理学研究方法
Dialogues Clin Neurosci. 2013 Mar;15(1):29-43. doi: 10.31887/DCNS.2013.15.1/kjellinger.
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Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses.骨髓间充质干细胞来源的可溶性 CCL5 通过淀粉样β激活,通过募集骨髓诱导的小胶质细胞免疫反应改善小鼠的阿尔茨海默病。
Stem Cells. 2012 Jul;30(7):1544-55. doi: 10.1002/stem.1125.
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J Alzheimers Dis. 2012;30(1):17-26. doi: 10.3233/JAD-2012-111964.
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Adult hippocampal neurogenesis and its role in Alzheimer's disease.成人海马神经发生及其在阿尔茨海默病中的作用。
Mol Neurodegener. 2011 Dec 22;6:85. doi: 10.1186/1750-1326-6-85.
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Neurobiol Aging. 2012 Mar;33(3):588-602. doi: 10.1016/j.neurobiolaging.2010.03.024. Epub 2010 May 14.
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Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease.颅内免疫监视支持大脑的保护性自身免疫功能:健康与疾病之间缺失的环节。
Mol Psychiatry. 2010 Apr;15(4):342-54. doi: 10.1038/mp.2010.31.
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Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior.间充质干细胞增加海马神经发生并逆转抑郁样行为。
Mol Psychiatry. 2010 Dec;15(12):1164-75. doi: 10.1038/mp.2009.110. Epub 2009 Oct 27.