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脑源性神经营养因子基因修饰骨髓间充质干细胞侧脑室移植对阿尔茨海默病大鼠认知功能的影响。

Effects of lateral ventricular transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene on cognition in a rat model of Alzheimer's disease.

机构信息

Department of Neurology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China.

Research Center for Bioengineering Technology, Hebei University, Baoding 071000, Hebei Province, China.

出版信息

Neural Regen Res. 2012 Feb 5;7(4):245-50. doi: 10.3969/j.issn.1673-5374.2012.04.001.

DOI:10.3969/j.issn.1673-5374.2012.04.001
PMID:25806063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4353094/
Abstract

In the present study, transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene into the lateral ventricle of a rat model of Alzheimer's disease, resulted in significant attenuation of nerve cell damage in the hippocampal CA1 region. Furthermore, brain-derived neurotrophic factor and tyrosine kinase B mRNA and protein levels were significantly increased, and learning and memory were significantly improved. Results indicate that transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene can significantly improve cognitive function in a rat model of Alzheimer's disease, possibly by increasing the levels of brain-derived neurotrophic factor and tyrosine kinase B in the hippocampus.

摘要

在本研究中，将脑源性神经营养因子基因修饰的骨髓间充质干细胞移植到阿尔茨海默病大鼠模型的侧脑室中，导致海马 CA1 区神经细胞损伤明显减轻。此外，脑源性神经营养因子和酪氨酸激酶 BmRNA 和蛋白水平明显增加，学习和记忆能力显著改善。结果表明，脑源性神经营养因子基因修饰的骨髓间充质干细胞移植可以显著改善阿尔茨海默病大鼠的认知功能，可能是通过增加海马脑源性神经营养因子和酪氨酸激酶 B 的水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5617/4353094/4b918f0a9c88/NRR-7-245-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5617/4353094/4b918f0a9c88/NRR-7-245-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5617/4353094/bf5d6ab83fd6/NRR-7-245-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5617/4353094/4941d9748827/NRR-7-245-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5617/4353094/763dd3b1ea18/NRR-7-245-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5617/4353094/f09906438c2f/NRR-7-245-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5617/4353094/bfe7f91d85f8/NRR-7-245-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5617/4353094/4b918f0a9c88/NRR-7-245-g008.jpg

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