Trachtman H, Del Pizzo R, Rao P, Rujikarn N, Sturman J A
Department of Pediatrics, State University of New York, Stony Brook.
Am J Hypertens. 1989 Dec;2(12 Pt 1):909-12. doi: 10.1093/ajh/2.12.909.
Taurine, a sulfur aminoacid, has been studied for a role in blood pressure regulation since it functions as a generalized inhibitory neurotransmitter and is found in high concentrations in the myocardium. We reinvestigated the magnitude of the hypotensive effect of chronic taurine administration to the spontaneously hypertensive rat (SHR) and the role of catecholamines in such an action. The SHR received either a 1% taurine solution or tap water to drink for 16 weeks. Taurine treatment caused a significant persistent reduction in blood pressure by 4 weeks that was maximal at 16 weeks (146 +/- 6 [exp.] v 182 +/- 5 [control] mm Hg, P less than .01). While this taurine-induced decline in blood pressure in the SHR was not accompanied by alterations in plasma epinephrine levels, there was a steady 235% increment in the norepinephrine concentration from 231 +/- 31 pg/mL initially to 542 +/- 126 pg/mL at completion of the study, P less than .02. The reduction in blood pressure was associated with decreased proteinuria in the taurine-treated SHR (9.6 +/- 4 [exp.] v 21.5 +/- 7 [control] mg/24 h, P less than .02) and less cardiac and renal hypertrophy. We conclude that taurine administration results in a 20 to 25% reduction in blood pressure in the SHR. The mechanism of this hypotensive action requires further study but is independent of changes in plasma catecholamine levels. The vasodepressor effect of taurine leads to less hypertensive injury to the kidney and heart in the SHR.
牛磺酸是一种含硫氨基酸，因其作为一种广泛存在的抑制性神经递质且在心肌中含量很高，所以人们对其在血压调节中的作用进行了研究。我们重新研究了长期给自发性高血压大鼠（SHR）注射牛磺酸后的降压效果大小以及儿茶酚胺在这一作用中的角色。SHR饮用1%的牛磺酸溶液或自来水，为期16周。4周时，牛磺酸治疗使血压持续显著降低，16周时达到最大降幅（实验值146±6[实验值]对对照组182±5[对照组]毫米汞柱，P<0.01）。虽然SHR中牛磺酸诱导的血压下降并未伴随血浆肾上腺素水平的改变，但去甲肾上腺素浓度从最初的231±31皮克/毫升稳步增加了235%，在研究结束时达到542±126皮克/毫升，P<0.02。血压降低与牛磺酸治疗的SHR蛋白尿减少有关（9.6±4[实验值]对21.5±7[对照组]毫克/24小时，P<0.02），且心脏和肾脏肥大程度减轻。我们得出结论，给SHR注射牛磺酸可使血压降低20%至25%。这种降压作用的机制需要进一步研究，但与血浆儿茶酚胺水平的变化无关。牛磺酸的血管降压作用可减轻SHR对肾脏和心脏的高血压损伤。
