Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Nutrients. 2024 Mar 26;16(7):946. doi: 10.3390/nu16070946.
Recently, we reported that during the hypertrophic phase (230 days old) of hereditary cardiomyopathy of the hamster (HCMH), short-term treatment (20 days) with 250 mg/kg/day of taurine prevents the development of hypertrophy in males but not in females. However, the mortality rate in non-treated animals was higher in females than in males. To verify whether the sex-dependency effect of taurine is due to the difference in the disease's progression, we treated the 230-day-old animals for a longer time period of 122 days. Our results showed that long-term treatment with low and high concentrations of taurine significantly prevents cardiac hypertrophy and early death in HCMH males ( < 0.0001 and < 0.05, respectively) and females ( < 0.01 and < 0.0001, respectively). Our results demonstrate that the reported sex dependency of short-term treatments with taurine is due to a higher degree of heart remodeling in females when compared to males and not to sex dependency. In addition, sex-dependency studies should consider the differences between the male and female progression of the disease. Thus, long-term taurine therapies are recommended to prevent remodeling and early death in hereditary cardiomyopathy.
最近，我们报道称在仓鼠遗传性心肌病（HCMH）的肥厚期（230 天），250mg/kg/天的牛磺酸短期（20 天）治疗可以预防雄性而不是雌性动物的肥大。然而，未经治疗的动物的死亡率在雌性中比雄性更高。为了验证牛磺酸的性别依赖性效应是否是由于疾病进展的差异，我们对 230 日龄的动物进行了更长时间（122 天）的治疗。我们的结果表明，低浓度和高浓度牛磺酸的长期治疗显著预防了 HCMH 雄性（分别为<0.0001 和<0.05）和雌性（分别为<0.01 和<0.0001）的心脏肥大和早期死亡。我们的结果表明，报告的牛磺酸短期治疗的性别依赖性是由于与雄性相比，雌性的心脏重构程度更高，而不是性别依赖性。此外，性别依赖性研究应考虑疾病在男性和女性之间进展的差异。因此，建议长期牛磺酸治疗以预防遗传性心肌病的重构和早期死亡。
