Behrangi Elham, Baniasadi Farzaneh, Esmaeeli Shooka, Hedayat Kosar, Goodarzi Azade, Azizian Zahra
Department of Dermatology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences, Tehran, Iran.
J Res Med Sci. 2015 Mar;20(3):281-3.
Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. It is most prevalent among young to middle-aged women. Although iron overload affects skin pigmentation, effect of iron deficiency on skin is not clear. So, we evaluated serum iron level, ferritin and total iron binding capacity (TIBC) level among nonpregnant women with and without melasma.
A cross-sectional case study was conducted in 2012 at university dermatologic department on 33 nonpregnant women with melasma (case) and 33 nonpregnant women without melasma (control). Serum iron level, TIBC and ferritin in the two groups was measured and compared.
Serum iron level was lower in the case group (85 ± 11) in comparison with control group (102 ± 9), but the difference was not significant (P: 0.9). Mean TIBC and Ferritin were higher in the case group (TIBC: 329.4 ± 29, ferritin: 6 ± 18) than the control group (TIBC: 329.3 ± 29, ferritin: 33 ± 6) without significant difference.
Although the serum iron level was lower in nonpregnant women with mealsma, it was not significant compared with those without melasma.
黄褐斑是一种常见的获得性疾病，其特征为面部出现轮廓不规则的对称性色素沉着斑，最常见于中青年女性。虽然铁过载会影响皮肤色素沉着，但缺铁对皮肤的影响尚不清楚。因此，我们评估了患有和未患有黄褐斑的非妊娠女性的血清铁水平、铁蛋白和总铁结合力（TIBC）水平。
2012年在大学皮肤科进行了一项横断面病例研究，对33名患有黄褐斑的非妊娠女性（病例组）和33名未患有黄褐斑的非妊娠女性（对照组）进行研究。测量并比较两组的血清铁水平、TIBC和铁蛋白。
病例组血清铁水平（85±11）低于对照组（102±9），但差异无统计学意义（P：0.9）。病例组的平均TIBC和铁蛋白水平（TIBC：329.4±29，铁蛋白：6±18）高于对照组（TIBC：329.3±29，铁蛋白：33±6），但差异无统计学意义。
虽然患有黄褐斑的非妊娠女性血清铁水平较低，但与未患黄褐斑的女性相比，差异无统计学意义。
